公开(公告)号：US10670605B2

公开(公告)日：2020-06-02

申请号：US15331745

申请日：2016-10-21

Applicant: The Scripps Research Institute

Inventor： Benjamin F. Cravatt ,  Keriann M. Backus ,  Bruno E. Correia ,  Megan M. Blewett ,  John R. Teijaro

IPC: G01N33/68 ,  C40B60/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/64 ,  G01N33/50

Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.