公开(公告)号：US11083717B2

公开(公告)日：2021-08-10

申请号：US16720160

申请日：2019-12-19

Applicant: The Texas A&M University System

Inventor： Manchi C M Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/44 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/541 ,  A61P33/02 ,  A61K31/423 ,  A61K31/496 ,  A61K31/498 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/7036 ,  A61K31/427 ,  A61K31/5355 ,  A61K31/353 ,  A61K31/517

Abstract: Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, one or more substituted quinols, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a combination thereof in an amount and formulation sufficient to sensitize the parasite to the drug, treating infection of a patient by a parasite with a drug, or to prevent symptomatic infection of a patient by a parasite with a drug.

公开(公告)号：US20190314381A1

公开(公告)日：2019-10-17

申请号：US16422594

申请日：2019-05-24

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Manchi CM Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/5377 ,  A61K31/501 ,  A61K31/496 ,  A61K31/454 ,  A61K31/423 ,  A61K31/498 ,  A61K31/44 ,  A61K31/428 ,  A61K31/4439

Abstract: A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, or prodrugs thereof, or a combination thereof, in an amount and formulation sufficient to inhibit a mycobacterium is disclosed.

公开(公告)号：US10543200B2

公开(公告)日：2020-01-28

申请号：US15754244

申请日：2016-08-26

Applicant: The Texas A&M University System

Inventor： Manchi C M Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/44 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/541 ,  A61P33/02 ,  A61K31/423 ,  A61K31/496 ,  A61K31/498 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/7036

Abstract: Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, one or more substituted quinols, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a combination thereof in an amount and formulation sufficient to sensitize the parasite to the drug, treating infection of a patient by a parasite with a drug, or to prevent symptomatic infection of a patient by a parasite with a drug.

公开(公告)号：US10300071B2

公开(公告)日：2019-05-28

申请号：US15248844

申请日：2016-08-26

Applicant: The Texas A&M University System

Inventor： Manchi C M Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/428 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/423 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501

Abstract: A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, or prodrugs thereof, or a combination thereof, in an amount and formulation sufficient to inhibit a mycobacterium is disclosed.