公开(公告)号：US20220251568A1

公开(公告)日：2022-08-11

申请号：US17171288

申请日：2021-02-09

Applicant: The Texas A&M University System

Inventor： Jiang Chang ,  Weijia Luo

IPC: C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  G01N33/573 ,  C12Q1/6886

Abstract: Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.

公开(公告)号：US20250051782A1

公开(公告)日：2025-02-13

申请号：US18893220

申请日：2024-09-23

Applicant: The Texas A&M University System

Inventor： Jiang Chang ,  Weijia Luo

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/6886 ,  G01N33/573

Abstract: Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.

公开(公告)号：US12129470B2

公开(公告)日：2024-10-29

申请号：US17171288

申请日：2021-02-09

Applicant: The Texas A&M University System

Inventor： Jiang Chang ,  Weijia Luo

IPC: C07H21/02 ,  A61K31/713 ,  A61K45/06 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/573

CPC classification number: C12N15/1137 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/6886 ,  G01N33/573 ,  C12N2310/14 ,  C12N2320/31

Abstract: Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.