公开(公告)号：US20230100536A1

公开(公告)日：2023-03-30

申请号：US17802823

申请日：2021-02-26

Applicant: The Trustees of Princeton University

Inventor： Aaron Trowbridge ,  Ciaran Seath ,  David W.C. MacMillan

IPC: C07D213/22 ,  C07D213/56 ,  C07D213/79 ,  C07D401/14 ,  C07F15/00 ,  C09K11/06

Abstract: In one aspect, transition metal complexes are described herein having composition and electronic structure for generating reactive labeling intermediates having lifetimes and diffusion radii advantageous for proximity-based labeling of various biomolecular species, including proteins, in intracellular and intercellular environments.