公开(公告)号：US20240328997A1

公开(公告)日：2024-10-03

申请号：US18587324

申请日：2024-02-26

申请人： The Trustees of the University of Pennsylvania

发明人： Aaron Timperman

IPC分类号： G01N27/447 ,  B01L3/00

CPC分类号： G01N27/44791 ,  B01L3/502761 ,  B01L2300/0645

摘要： A method, comprising: determining electrophoretic mobility associated with a particle in a transverse alternating force microfluidic channel; determining a size of the particle based at least in part on one of Brownian motion of a particle or one or more images of the particle. A system comprising: a microfluidic channel; a plurality of electrodes oriented transverse to the microfluidic channel, the plurality of electrodes comprising an alternating electric field; and a classification system configured to: determine one or more of the following: an electrophoretic mobility associated with a particle in the transverse AC microfluidic channel and/or determine, based at least in part on the electrophoretic motion, and size from image analysis or Brownian motion of a particle or one or more images of the particle, particle shape, particle deformability, for recognition of surface characteristics, such as assaying for receptors and ligands, and to perform electroporation.