公开(公告)号：US20210260144A1

公开(公告)日：2021-08-26

申请号：US17236918

申请日：2021-04-21

Applicant: The Trustees of the University of Pennsylvania ,  Monell Chemical Senses Center ,  GeneOne Life Science, Inc.

Inventor： Noam A. Cohen ,  Robert J. Lee ,  Susan R. Weiss ,  Joel N. Maslow ,  Christine C. Roberts ,  Sara Cherry ,  Michael Kohanski ,  Nithin D. Adappa ,  James N. Palmer ,  Li Hui Tan

IPC: A61K36/185 ,  G01N33/68 ,  G01N33/566 ,  A61K31/167 ,  A61K31/365 ,  A61K31/4709 ,  A61K31/513 ,  A61K45/06 ,  C12Q1/6883 ,  G01N33/50

Abstract: The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.

公开(公告)号：US20230144186A1

公开(公告)日：2023-05-11

申请号：US17996853

申请日：2021-04-21

Applicant: The Trustees of the University of Pennsylvania

Inventor： Noam Cohen ,  Robert J. Lee ,  Susan R. Weiss ,  Joel N. Maslow ,  Christine C. Roberts ,  Sara Cherry ,  Michael Kohanski ,  Nithin D. Adappa ,  James N. Palmer ,  Li Hui Tan

IPC: A61K31/49 ,  G01N33/569 ,  A61K9/00 ,  A61P31/14

CPC classification number: A61K31/49 ,  G01N33/56983 ,  A61K9/0043 ,  A61P31/14 ,  G01N2333/165

Abstract: The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.