专利检索 ap:("The U.S.A, as represented by the Secretary, Department of Health AND Human Services") AND inv:"Jessica Diana Hong" 第 1 页

1.

发明公开
IGG4 HINGE-CONTAINING CHIMERIC ANTIGEN RECEPTORS TARGETING GLYPICAN-1 (GPC1) FOR TREATING SOLID TUMORS 审中-公开

公开(公告)号：US20230340146A1

公开(公告)日：2023-10-26

申请号：US18020191

申请日：2021-08-10

申请人： The U.S.A, as represented by the Secretary, Department of Health and Human Services

发明人： Mitchell Ho , Nan Li , Jessica Diana Hong

IPC分类号： C07K14/725 , C12N15/86 , C07K16/30 , A61P35/00

CPC分类号： C07K16/303 , A61P35/00 , C07K14/7051 , C12N15/86 , C07K2317/53 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2319/02 , C07K2319/03

摘要： Optimized chimeric antigen receptors (CARs) targeting glypican-1 (GPC1) that include a 12-amino acid hinge region from IgG4 are described. The optimized CARs include a transmembrane domain from either CD8 or CD28. Immune cells, such as T cells or natural killer cells, expressing the optimized CARs can be used to treat GPC1-positive solid tumors.

2.

发明公开
SINGLE DOMAIN ANTIBODIES TARGETING SARS CORONAVIRUS SPIKE PROTEIN AND USES THEREOF 审中-公开

公开(公告)号：US20230391852A1

公开(公告)日：2023-12-07

申请号：US18033656

申请日：2021-10-26

申请人： The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Mitchell Ho , Jessica Diana Hong

IPC分类号： C07K16/10 , A61K47/68 , G01N33/569

CPC分类号： C07K16/1003 , A61K47/6841 , A61K47/6817 , G01N33/56983 , C07K2317/569 , C07K2319/30 , C07K2317/31 , C07K2317/92 , C07K2317/22 , C07K2317/76 , G01N2469/10 , G01N2333/165

摘要： Polypeptides that specifically bind the spike (S) protein of human coronavirus, selected from six camel VHH single domain antibody phage display libraries, are described. The S protein-specific polypeptides disrupt binding of the SARS-CoV-2 and/or SARS-CoV S protein to the cellular receptor ACE2, which is important for neutralization of the virus. Use of the S protein-specific polypeptides for the diagnosis and treatment of SARS-CoV-2 and/or SARS-CoV is described.