专利检索 ap:("The United States of America, as represented by the Secretary, Depart. of Health AND Human Services") AND inv:"Jay A. Berzofsky" 第 1 页

1.

发明公开
ADJUVANTED MUCOSAL SUBUNIT VACCINES FOR PREVENTING SARS-COV-2 TRANSMISSION AND INFECTION 审中-公开

公开(公告)号：US20240173399A1

公开(公告)日：2024-05-30

申请号：US18275925

申请日：2022-02-04

申请人： The United States of America, as represented by the Secretary, Depart. of Health and Human Services

发明人： Jay A. Berzofsky , Yongjun Sui

IPC分类号： A61K39/215 , A61K31/713 , A61K38/20 , A61K39/00 , C12N15/117

CPC分类号： A61K39/215 , A61K31/713 , A61K38/2086 , C12N15/117 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , C12N2770/20034

摘要： Immunogenic compositions that include SARS-CoV-2 spike (S) protein, S1 protein, or S2 protein, and an adjuvant, such as alum, or a combination of CpG oligodeoxynucleotide, Poly I:C, and IL-15, and nanoparticle compositions that include SARS-CoV-2 S protein, S1 protein, or S2 protein, and CpG oligonucleotide, poly(I:C), and IL-15, are provided. Also provided are methods of using such compositions, for example a prime intramuscular administration followed by one or more intranasal boosters that include the disclosed nanoparticles, to generate an immune response to SARS-CoV-2 in a subject, for example respiratory mucosal immunity, for example to prevent SARS-CoV-2 infection or transmission to other subjects.