专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Ser.") AND inv:"Peter Collins" 第 1 页

1.

发明公开
RECOMBINANT HUMAN/BOVINE PARAINFLUENZA VIRUS 1 (HPIV1) EXPRESSING A CHIMERIC RSV/HPIV1 F PROTEIN AND USES THEREOF 审中-公开

公开(公告)号：US20230287055A1

公开(公告)日：2023-09-14

申请号：US18162530

申请日：2023-01-31

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser.

发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan

IPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155

CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155 , A61K2039/5256

摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.