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公开(公告)号：US20180011106A1
公开(公告)日：2018-01-11
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Board of Regents of the University of Nebraska , University of Rochester , University of Arizona, Tech Transfer Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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公开(公告)号：US10697975B2
公开(公告)日：2020-06-30
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Board of Regents of the University of Nebraska , University of Rochester , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , G01N33/68 , G16B25/00 , C12Q1/6886 , G16B40/00
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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