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公开(公告)号：US10697975B2
公开(公告)日：2020-06-30
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Board of Regents of the University of Nebraska , University of Rochester , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , G01N33/68 , G16B25/00 , C12Q1/6886 , G16B40/00
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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公开(公告)号：US11028444B2
公开(公告)日：2021-06-08
申请号：US15965510
申请日：2018-04-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Arizona Board of Regents on Behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat de Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Würzburg
发明人： Lisa M. Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaløy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George W. Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： G01N33/48 , C12Q1/6886 , G01N33/574
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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公开(公告)号：US20180011106A1
公开(公告)日：2018-01-11
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Board of Regents of the University of Nebraska , University of Rochester , University of Arizona, Tech Transfer Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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公开(公告)号：US11646099B2
公开(公告)日：2023-05-09
申请号：US16713528
申请日：2019-12-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Mayo Foundation for Medical Education and Research , Julius-Maximilians-University of Würzburg , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Hospital Clinic de Barcelona , Universitat de Barcelona , Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Robert Bosch Gesellschaft fuer medizinische Forschung mbH , Oregon Health & Science University , City of Hope , The Cleveland Clinic Foundation
发明人： Louis M. Staudt , Christian Steidl , Anja Mottok , George W. Wright , David William Scott , Lisa M. Rimsza , Andreas Rosenwald , Randy Gascoyne , Timothy Greiner , Dennis Weisenburger , Erlend B. Smeland , Jan Delabie , Elias Campo Guerri , German Ott , Rita Braziel , Elaine S. Jaffe , Kai Fu , Wing C. Chan , Joo Song , James R. Cook
IPC分类号： G01N33/48 , G16B5/00 , G16B25/10 , C12Q1/6886
CPC分类号： G16B5/00 , C12Q1/6886 , G16B25/10 , C12Q2600/112 , C12Q2600/158
摘要： In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.
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公开(公告)号：US11725248B2
公开(公告)日：2023-08-15
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Julius-Maximilians—University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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公开(公告)号：US20180245165A1
公开(公告)日：2018-08-30
申请号：US15965510
申请日：2018-04-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Arizona Board of Regents on Behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat de Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Würzburg
发明人： Lisa M. Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaløy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George W. Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： C12Q1/6886 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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公开(公告)号：US20190153539A1
公开(公告)日：2019-05-23
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the secretary, Dep. of Health and Human Service , British Columbia Cancer Agency Branch , Julius-Maximilians - University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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