公开(公告)号：US20240270814A1

公开(公告)日：2024-08-15

申请号：US18583139

申请日：2024-02-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Drew C. Deniger ,  Steven A. Rosenberg ,  Anna Pasetto ,  Rami Yoseph ,  Winifred M. Lo ,  Yong-Chen Lu ,  Maria R. Parkhurst ,  Paul F. Robbins ,  Parisa Malekzadeh

IPC分类号： C07K14/725 ,  A61K35/17 ,  C12N5/0783 ,  G01N33/574

CPC分类号： C07K14/7051 ,  A61K35/17 ,  C12N5/0636 ,  G01N33/574

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US20240209059A1

公开(公告)日：2024-06-27

申请号：US18423020

申请日：2024-01-25

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Eric Tran ,  Yong-Chen Lu ,  Anna Pasetto ,  Paul F. Robbins ,  Steven A. Rosenberg ,  Zhili Zheng

IPC分类号： C07K14/725 ,  A61P35/00 ,  C07K14/82 ,  C12N15/85 ,  G01N33/574

CPC分类号： C07K14/7051 ,  A61P35/00 ,  C07K14/82 ,  C12N15/85 ,  G01N33/57407 ,  A61K38/00 ,  G01N2333/7051

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US20210300988A1

公开(公告)日：2021-09-30

申请号：US17345390

申请日：2021-06-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Eric Tran ,  Yong-Chen Lu ,  Anna Pasetto ,  Paul F. Robbins ,  Steven A. Rosenberg ,  Zhili Zheng

IPC分类号： C07K14/725 ,  C07K14/82 ,  G01N33/574 ,  A61P35/00 ,  C12N15/85

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.