专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Servic") AND inv:"Parisa Malekzadeh" 第 1 页

1.

发明公开
T CELL RECEPTORS RECOGNIZING MUTATED P53 审中-公开

公开(公告)号：US20240270814A1

公开(公告)日：2024-08-15

申请号：US18583139

申请日：2024-02-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Drew C. Deniger , Steven A. Rosenberg , Anna Pasetto , Rami Yoseph , Winifred M. Lo , Yong-Chen Lu , Maria R. Parkhurst , Paul F. Robbins , Parisa Malekzadeh

IPC分类号： C07K14/725 , A61K35/17 , C12N5/0783 , G01N33/574

CPC分类号： C07K14/7051 , A61K35/17 , C12N5/0636 , G01N33/574

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.