公开(公告)号：US20240294665A1

公开(公告)日：2024-09-05

申请号：US18663557

申请日：2024-05-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Qiong J. Wang ,  Zhiya Yu ,  James C. Yang

IPC分类号： C07K16/30 ,  A61K35/17 ,  A61P35/00 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/7153 ,  C07K16/2875 ,  A61K35/17 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33

摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.