公开(公告)号：US12018051B2

公开(公告)日：2024-06-25

申请号：US18162530

申请日：2023-01-31

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Collins ,  Bo Liang ,  Shirin Munir ,  Anne Schaap Nutt ,  Ursula Buchholz ,  Natalie Mackow ,  Peter Kwong ,  Barney Graham ,  Jason McLellan

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61P31/14 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61P31/14 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/03 ,  C07K2319/033 ,  C12N2760/00022 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18641 ,  C12N2760/18643 ,  C12N2760/18671 ,  C12N2760/18722 ,  C12N2760/18734 ,  C12N2760/18741 ,  C12N2760/18743 ,  C12N2760/18771

摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

公开(公告)号：US11975063B2

公开(公告)日：2024-05-07

申请号：US17590631

申请日：2022-02-01

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Peter L. Collins ,  Ursula J. Buchholz ,  Bo Liang ,  Shirin Munir

IPC分类号： A61K39/12 ,  A61K39/00 ,  C07K14/005 ,  C12N15/86

CPC分类号： A61K39/12 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  A61K2039/575 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2760/18643

摘要： Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing Respiratory Syncytial Virus (RSV) G protein or a recombinant RSV G protein, as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the RSV G protein or the recombinant RSV G protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to RSV and HPIV3 in a subject.

公开(公告)号：US11591372B2

公开(公告)日：2023-02-28

申请号：US16877319

申请日：2020-05-18

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Collins ,  Bo Liang ,  Shirin Munir ,  Anne Schaap Nutt ,  Ursula Buchholz ,  Natalie Mackow ,  Peter Kwong ,  Barney Graham ,  Jason McLellan

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  A61K39/155 ,  A61K39/00

摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

公开(公告)号：US10654898B2

公开(公告)日：2020-05-19

申请号：US15545218

申请日：2016-01-20

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Collins ,  Bo Liang ,  Shirin Munir ,  Anne Schaap Nutt ,  Ursula Buchholz ,  Natalie Mackow ,  Peter Kwong ,  Barney Graham ,  Jason McLellan

IPC分类号： C07K14/005 ,  A61P31/14 ,  A61K39/155 ,  A61K39/12 ,  A61K39/00

摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.