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1.发明授权公开(公告)号：US09187457B2
公开(公告)日：2015-11-17
申请号：US13897330
申请日：2013-05-17
申请人： The United States of America as represented by the Secretary of the Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： A61K51/00 , C07D239/88 , C07D217/24 , A61K31/47 , A61P35/00 , A61K31/167 , A61K31/517 , C07C233/01 , C07D405/06 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04 , A61K49/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
摘要翻译： 公开了可用作选择性TSHR激动剂的氧代 - 氢喹唑啉。 该化合物可用于检测或治疗甲状腺癌或治疗骨退行性疾病。
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公开(公告)号：US09296729B2
公开(公告)日：2016-03-29
申请号：US14243821
申请日：2014-04-02
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wenwei Huang , Gerd Krause , Gunnar Kleinau , Wei Zheng
IPC分类号： C07D405/06 , C07D239/91 , A61K49/00 , A61K51/00 , C07D401/06 , C07D405/14 , C07D487/04 , A61K31/517
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US20160024023A1
公开(公告)日：2016-01-28
申请号：US14869318
申请日：2015-09-29
申请人： The Government of the United States of America as represented by the Secretary of the Department of , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： C07D239/91 , A61K31/517 , A61K51/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US09458141B2
公开(公告)日：2016-10-04
申请号：US14869318
申请日：2015-09-29
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： A61K51/00 , C07D239/88 , C07D217/24 , A61K31/47 , A61P35/00 , A61K31/167 , A61K31/517 , C07C233/01 , C07D405/06 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04 , A61K49/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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5.发明申请公开(公告)号：US20130251631A1
公开(公告)日：2013-09-26
申请号：US13897330
申请日：2013-05-17
申请人： Forschungsverbund Berlin E.V. , The Government of the United States of America as represented by the Secretary of the Department of
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： C07D405/06 , A61K51/00 , A61K31/517
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
摘要翻译： 公开了可用作选择性TSHR激动剂的氧代 - 氢喹唑啉。 该化合物可用于检测或治疗甲状腺癌或治疗骨退行性疾病。
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6.发明申请公开(公告)号：US20140301944A1
公开(公告)日：2014-10-09
申请号：US14243821
申请日：2014-04-02
申请人： Forschungsverbund Berlin E.V. , The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wenwei Huang , Gerd Krause , Gunnar Kleinau , Wei Zheng
IPC分类号： C07D405/06 , C07D239/91 , A61K31/517 , A61K49/00 , A61K51/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
摘要翻译： 公开了可用作选择性TSHR激动剂的氧代 - 氢喹唑啉。 该化合物可用于检测或治疗甲状腺癌或治疗骨退行性疾病。
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