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公开(公告)号：US09296729B2
公开(公告)日：2016-03-29
申请号：US14243821
申请日：2014-04-02
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wenwei Huang , Gerd Krause , Gunnar Kleinau , Wei Zheng
IPC分类号： C07D405/06 , C07D239/91 , A61K49/00 , A61K51/00 , C07D401/06 , C07D405/14 , C07D487/04 , A61K31/517
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US09458141B2
公开(公告)日：2016-10-04
申请号：US14869318
申请日：2015-09-29
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： A61K51/00 , C07D239/88 , C07D217/24 , A61K31/47 , A61P35/00 , A61K31/167 , A61K31/517 , C07C233/01 , C07D405/06 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04 , A61K49/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US20210246137A1
公开(公告)日：2021-08-12
申请号：US17237351
申请日：2021-04-22
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services , Loyola University of Chicago
发明人： Wenwei Huang , Hao Li , Wei Sun , Xiuli Huang , Paresma R. Patel , Hangmao Sun , Wei Zheng , Xiao Lu , Philip E. Sanderson , Myunghoon Kim , Meghan J. Orr , Gregory J. Tawa , Kim C. Williamson
IPC分类号： C07D471/04 , A61P33/06 , C07D487/04 , C07D487/08 , C07D519/00
摘要： Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
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公开(公告)号：US20190315740A1
公开(公告)日：2019-10-17
申请号：US16341000
申请日：2017-10-13
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services , Loyola University of Chicago
发明人： Wenwei Huang , Hao Li , Wei Sun , Xiuli Huang , Paresma R. Patel , Hangmao Sun , Wei Zheng , Xiao Lu , Philip E. Sanderson , Myunghoon Kim , Meghan J. Orr , Gregory J. Tawa , Kim C. Williamson
IPC分类号： C07D471/04 , C07D487/04 , A61P33/06 , C07D487/08 , C07D519/00
摘要： Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
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公开(公告)号：US11471443B2
公开(公告)日：2022-10-18
申请号：US16861281
申请日：2020-04-29
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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公开(公告)号：US10561666B2
公开(公告)日：2020-02-18
申请号：US15350299
申请日：2016-11-14
申请人： New York University , The United States of America, as Represented by the Secretary, Department of Health and Human Services
发明人： Dan Littman , Jun R. Huh , Ruili Huang , Wenwei Huang , Erika Elaine Englund
IPC分类号： A61K31/55 , A61K31/12 , A61K31/33 , A61K31/535 , A61K31/4453 , A61K31/4525 , A61K31/4025 , A61K31/404 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/5377 , C07C235/34 , C07C235/36 , C07D211/16 , C07D307/52 , C07D317/54 , C07D317/60 , C07D403/14 , C07D405/06 , C07D211/06 , C07D401/10 , A61K31/496 , C07D307/81 , C07D413/06 , C07D413/14
摘要： Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
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公开(公告)号：US10555942B2
公开(公告)日：2020-02-11
申请号：US16156124
申请日：2018-10-10
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , THE JOHNS HOPKINS UNIVERSITY , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Hengli Tang , Emily M. Lee , Anil Mathew Tharappel , Hongjun Song , Guo-Li Ming , Wei Zheng , Miao Xu , Shu Yang , Ruili Huang , Wenwei Huang , Khalida Shamim , Hao Li
IPC分类号： A61K31/4745 , A61K45/06 , A61P31/14
摘要： The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.
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公开(公告)号：US11753408B2
公开(公告)日：2023-09-12
申请号：US17237351
申请日：2021-04-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Loyola University of Chicago
发明人： Wenwei Huang , Hao Li , Wei Sun , Xiuli Huang , Paresma R. Patel , Hangmao Sun , Wei Zheng , Xiao Lu , Philip E. Sanderson , Myunghoon Kim , Meghan J. Orr , Gregory J. Tawa , Kim C. Williamson
IPC分类号： C07D471/14 , A61K31/4375 , C07D471/04 , A61P33/06 , C07D487/04 , C07D487/08 , C07D519/00
CPC分类号： C07D471/04 , A61P33/06 , C07D487/04 , C07D487/08 , C07D519/00
摘要： Disclosed are compounds of formula (I) and formula (II):
wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.-
公开(公告)号：US10940188B2
公开(公告)日：2021-03-09
申请号：US16779132
申请日：2020-01-31
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE JOHNS HOPKINS UNIVERSITY
发明人： Hengli Tang , Emily M. Lee , Yichen Cheng , Yi Zhou , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Menghang Xia , Hongjun Song , Guo-Li Ming , Zhexing Wen
IPC分类号： A61K38/55 , A61K31/24 , A61K31/609 , A61K38/43 , A61K45/06 , C07C239/02 , C07C239/08 , A61K38/00
摘要： The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.
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公开(公告)号：US11878004B2
公开(公告)日：2024-01-23
申请号：US17809353
申请日：2022-06-28
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/245 , A61K31/336 , A61K31/352 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4535 , A61K31/4709 , A61K31/4741 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/554 , A61P31/14
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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