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公开(公告)号：US11821903B2
公开(公告)日：2023-11-21
申请号：US16644926
申请日：2018-09-06
发明人： Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood
CPC分类号： G01N33/6845 , G01N21/6428 , G01N33/5308
摘要： A sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel and a reporter dye; wherein the protein barrel defines a lumen; the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors.
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公开(公告)号：US20220178931A1
公开(公告)日：2022-06-09
申请号：US17437014
申请日：2020-03-06
发明人： Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood , James Christopher Norman , Cassie Jemma Clarke
IPC分类号： G01N33/574 , G01N21/64
摘要： A method of diagnosing, staging or monitoring cancer, the method comprising the steps of: (a) providing a sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel that comprises five or more alpha helices arranged as an alpha-helical barrel, and a reporter dye, wherein the protein barrel defines a lumen, the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors; (b) contacting the sensor array with a sample obtained from a patient; and then (c) comparing the sensor array to a predetermined standard.
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公开(公告)号：US20210072253A1
公开(公告)日：2021-03-11
申请号：US16644926
申请日：2018-09-06
发明人： Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood
摘要： A sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel and a reporter dye; wherein the protein barrel defines a lumen; the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors.
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