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公开(公告)号:US12121593B2
公开(公告)日:2024-10-22
申请号:US17348048
申请日:2021-06-15
CPC分类号: A61K48/005 , C12N15/86 , C12N2750/14143 , C12N2830/48 , C12N2830/50
摘要: The application provides gene therapies for treating monogenic forms of nephrotic syndrome.
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公开(公告)号:US20240085631A1
公开(公告)日:2024-03-14
申请号:US18370785
申请日:2023-09-20
发明人: Damien Bonneau , Mark Thompson
CPC分类号: G02B6/2861 , G02B6/262 , H01P9/00
摘要: An optical device includes a first multi-mode waveguide, a first optical coupler coupled to the first multi-mode waveguide, the first coupler being tapered and curved, and a first single-mode waveguide having a first end coupled to the first optical coupler. The optical device maybe used in an optical delay device. A method of propagating light in a first multi-mode waveguide toward a first optical coupler, propagating the light in the first optical coupler toward a first single-mode waveguide, the first optical coupler being tapered and curved, and propagating the light along the first single-mode waveguide is also disclosed.
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公开(公告)号:US11821903B2
公开(公告)日:2023-11-21
申请号:US16644926
申请日:2018-09-06
发明人: Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood
CPC分类号: G01N33/6845 , G01N21/6428 , G01N33/5308
摘要: A sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel and a reporter dye; wherein the protein barrel defines a lumen; the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors.
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公开(公告)号:US20230365922A1
公开(公告)日:2023-11-16
申请号:US18245560
申请日:2021-09-17
CPC分类号: C12N5/0068 , C12M25/14 , C12N5/0644
摘要: The invention provides a method for generating platelets or platelet-like particles comprising passing a source material comprising one or more cells through a micro-passage to produce a passaged material comprising platelets or platelet-like particles. The invention also provides platelets and platelet-like particles produced using the method and uses thereof.
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公开(公告)号:US11667638B2
公开(公告)日:2023-06-06
申请号:US16326615
申请日:2017-08-17
IPC分类号: C07D471/18 , B01J31/18 , B01J31/24
CPC分类号: C07D471/18 , B01J31/1815 , B01J31/1825 , B01J31/2409
摘要: Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.
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公开(公告)号:US20220333077A1
公开(公告)日:2022-10-20
申请号:US17760658
申请日:2020-09-21
摘要: A method of making an erythroid cell comprising elevated levels of a target protein or polypeptide, the method comprising: a) provision of an erythroid progenitor which is able to express the target protein or polypeptide; b) expression of the target protein or polypeptide; and c) maturation of the erythroid progenitor into the erythroid cell; wherein during maturation of the erythroid progenitor into the erythroid cell, the target protein or polypeptide is configured and/or inhibited such that ubiquitination of the target protein or polypeptide is hindered or prevented. Erythroid cells, pharmaceutical compositions and methods of use related thereto, and a method of screening for proteins or polypeptides degraded by ubiquitination during maturation of an erythroid progenitor are also provided.
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公开(公告)号:US20210060174A1
公开(公告)日:2021-03-04
申请号:US16644354
申请日:2018-09-07
发明人: Adam Willis PERRIMAN , Robert Christopher DELLER , Wenjin XIAO , Thomas Iain Phillip GREEN , Benjamin Michael CARTER , Graham John DAY , Rosalia Cuahtecontzi DELINT
摘要: There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; orb) is a protein which does not comprise a —CH2C(O)NCH3(CH2)3NCH3)2H+ linker covalently bonded to an amino acid side chain.
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公开(公告)号:US10849939B2
公开(公告)日:2020-12-01
申请号:US15982739
申请日:2018-05-17
发明人: Tristan Cogan , Jenny Bailey
IPC分类号: A61K35/744 , A23L33/135 , A23C9/123 , C12N1/20 , A23L2/52 , A23C9/12 , C12R1/46 , C12R1/44
摘要: A probiotic organism which is capable of proliferation in iron-rich media, an environment which is generally unfavourable to probiotic organisms, is described.
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公开(公告)号:US20200231685A1
公开(公告)日:2020-07-23
申请号:US16722952
申请日:2019-12-20
申请人: The University of Bristol , The Govt. of the U.S.A as represented by the Secretary of the Department of Health and Human Service
发明人: Richard LEE , Andrew Dick , Lauren Schewitz Bowers , Robert Nussenblatt , Igal Gery , Lai Wei
摘要: The present invention relates to a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells, for use in a method for the treatment of an inflammatory disease. The invention also relates to a method for treating an inflammatory disease by administering a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells. In addition, the invention relates to a method for identifying a subject likely to be resistant to steroid treatment, as well as a subject likely to benefit from treatment with a calcineurin inhibitor.
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公开(公告)号:US10541809B2
公开(公告)日:2020-01-21
申请号:US15556762
申请日:2016-03-08
发明人: Mark Godfrey , Mark Thompson , Philip Sibson
摘要: There is provided an integrated-optic transmitter for transmitting light pulses to a further optical apparatus for generating a quantum cryptographic key according to at least one quantum cryptography technique. There is also provided an integrated-optic receiver for generating a quantum cryptographic key from light pulses received from a further optical apparatus. The transmitter apparatus splits incoming light into two paths to temporally separate the split light pulses and controls the output intensity of each split pulse as well as the phase of at least one of the split pulses. The receiver apparatus receives first and second light pulses and controls the output intensity of each said pulse between a first and a second optical detector. The light input into the second detector passes through an integrated element that controls the amount of light output into two paths that recombine before at least a portion is output to the second detector.
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