公开(公告)号：US12048682B2

公开(公告)日：2024-07-30

申请号：US17855327

申请日：2022-06-30

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Christina Chan ,  Wenbo Han

IPC: A61K31/343 ,  A61K45/06 ,  A61K47/68 ,  A61N5/10 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K31/343 ,  A61K45/06 ,  A61K47/6803 ,  A61P35/00 ,  A61P37/00 ,  A61N5/10

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.

公开(公告)号：US11246877B2

公开(公告)日：2022-02-15

申请号：US16302185

申请日：2017-05-22

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xiaopin Duan ,  Christina Chan ,  Wenbo Han

IPC: A61K31/66 ,  A61K47/54 ,  A61P35/00 ,  A61K9/127 ,  A61K31/337 ,  A61K31/357 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/136 ,  A61K31/7068 ,  A61K31/4745 ,  C12N15/11 ,  A61K31/475 ,  A61K9/51 ,  A61K45/06

Abstract: Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.

公开(公告)号：US20190269706A1

公开(公告)日：2019-09-05

申请号：US16302185

申请日：2017-05-22

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xiaopin Duan ,  Christina Chan ,  Wenbo Han

IPC: A61K31/66 ,  A61P35/00 ,  A61K9/127 ,  A61K47/54

Abstract: Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.

公开(公告)号：US20230036839A1

公开(公告)日：2023-02-02

申请号：US17855327

申请日：2022-06-30

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Christina Chan ,  Wenbo Han

IPC: A61K31/343 ,  A61K47/68 ,  A61P35/00 ,  A61P37/00 ,  A61K45/06

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.

公开(公告)号：US20200261403A1

公开(公告)日：2020-08-20

申请号：US16859594

申请日：2020-04-27

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Christina Chan ,  Wenbo Han

IPC: A61K31/343 ,  A61K47/68 ,  A61P35/00 ,  A61P37/00 ,  A61K45/06

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.

公开(公告)号：US20240042045A1

公开(公告)日：2024-02-08

申请号：US18022296

申请日：2021-08-23

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xiaomin Jiang ,  Wenbo Han ,  Xuanyu Feng

IPC: A61K47/54 ,  A61K47/69 ,  A61K45/06 ,  A61P35/00 ,  C07J43/00

CPC classification number: A61K47/554 ,  A61K47/6929 ,  A61K45/06 ,  A61P35/00 ,  C07J43/003 ,  B82Y5/00

Abstract: Prodrugs that target the low-density lipoprotein receptor (LDLR) and that comprise acid and/or enzyme cleavable acetal- or oxybenzyloxy-linked carbonate or carbamate bonds are described. Also described are core-shell nanoparticles comprising metal-organic framework cores or nanoscale metal bisphosphate coordination polymer cores, and lipid coating layers containing the prodrugs. The nanoparticle core can optionally contain one or more hydrophilic chemotherapeutic agents. The prodrugs and nanoparticles can be used in methods of treating cancer. For instance, the presently disclosed nanoparticles can be used for the co-delivery of multiple chemotherapeutic agents in methods providing increased accumulation of chemotherapeutic agents to a tumor compared to delivery of mixtures of free chemotherapeutic agents.

公开(公告)号：US20190314324A1

公开(公告)日：2019-10-17

申请号：US16381774

申请日：2019-04-11

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Christina Chan ,  Wenbo Han

IPC: A61K31/343 ,  A61K47/68 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.