公开(公告)号：US20240042045A1

公开(公告)日：2024-02-08

申请号：US18022296

申请日：2021-08-23

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xiaomin Jiang ,  Wenbo Han ,  Xuanyu Feng

IPC: A61K47/54 ,  A61K47/69 ,  A61K45/06 ,  A61P35/00 ,  C07J43/00

CPC classification number: A61K47/554 ,  A61K47/6929 ,  A61K45/06 ,  A61P35/00 ,  C07J43/003 ,  B82Y5/00

Abstract: Prodrugs that target the low-density lipoprotein receptor (LDLR) and that comprise acid and/or enzyme cleavable acetal- or oxybenzyloxy-linked carbonate or carbamate bonds are described. Also described are core-shell nanoparticles comprising metal-organic framework cores or nanoscale metal bisphosphate coordination polymer cores, and lipid coating layers containing the prodrugs. The nanoparticle core can optionally contain one or more hydrophilic chemotherapeutic agents. The prodrugs and nanoparticles can be used in methods of treating cancer. For instance, the presently disclosed nanoparticles can be used for the co-delivery of multiple chemotherapeutic agents in methods providing increased accumulation of chemotherapeutic agents to a tumor compared to delivery of mixtures of free chemotherapeutic agents.

公开(公告)号：US12042788B2

公开(公告)日：2024-07-23

申请号：US16999818

申请日：2020-08-21

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xuanyu Feng ,  Pengfei Ji

IPC: B01J31/16 ,  B01J21/08 ,  C07D307/06 ,  C07D307/20 ,  C07D307/79 ,  C07D309/30

CPC classification number: B01J31/1691 ,  B01J21/08 ,  C07D307/06 ,  C07D307/20 ,  C07D307/79 ,  C07D309/30 ,  B01J2231/005 ,  B01J2231/325 ,  B01J2231/326 ,  B01J2231/342 ,  B01J2231/485 ,  B01J2531/48 ,  B01J2531/824

Abstract: Lewis acidic metal-organic framework (MOF) materials comprising triflate-coordinated metal nodes are described. The materials can be used as heterogenous catalysts in a wide range of organic group transformations, including Diels-Alder reactions, epoxide-ring opening reactions, Friedel-Crafts acylation reactions and alkene hydroalkoxylation reactions. The MOFs can also be prepared with metallated organic bridging ligands to provide heterogenous catalysts for tandem reactions and/or prepared as composites with support particles for use in columns of continuous flow reactor systems. Methods of preparing and using the MOF materials and their composites are also described.

公开(公告)号：US20210053042A1

公开(公告)日：2021-02-25

申请号：US16999818

申请日：2020-08-21

Applicant: The University of Chicago

Inventor： Wenbin Lin ,  Xuanyu Feng ,  Pengfei Ji

IPC: B01J31/16 ,  B01J21/08 ,  C07D307/79 ,  C07D307/06 ,  C07D307/20 ,  C07D309/30

Abstract: Lewis acidic metal-organic framework (MOF) materials comprising triflate-coordinated metal nodes are described. The materials can be used as heterogenous catalysts in a wide range of organic group transformations, including Diels-Alder reactions, epoxide-ring opening reactions, Friedel-Crafts acylation reactions and alkene hydroalkoxylation reactions. The MOFs can also be prepared with metallated organic bridging ligands to provide heterogenous catalysts for tandem reactions and/or prepared as composites with support particles for use in columns of continuous flow reactor systems. Methods of preparing and using the MOF materials and their composites are also described.