专利检索 ap:("The University of Chicago" OR "Inova Health System" OR "The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.") AND inv:"Ayman Al-Hendy" 第 1 页

1.

发明公开
Methods of Differentiating a Malignant Tumor from a Non-Malignant Tumor 审中-公开

公开(公告)号：US20230280349A1

公开(公告)日：2023-09-07

申请号：US18176909

申请日：2023-03-01

申请人： The University of Chicago , Inova Health System , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： Ayman Al-Hendy , Hiba Alkelani , Thomas Patrick Conrads , George Larry Maxwell , Nicholas William Bateman , Waleed Barakat

IPC分类号： G01N33/574

CPC分类号： G01N33/57488 , G01N2800/7028

摘要： In aspects, the disclosure provides a method of differentiating a malignant tumor from a non-malignant tumor in a mammal having a tumor comprising determining in a sample from the mammal the level of one or more of: (1) transthyretin (TTR) RNA or protein, (2) dual oxidase 2 (DUOX2) RNA or protein, and (3) G-protein coupled receptor 179 (GPR179) RNA or protein.

2.

发明公开
USE OF DOXERCALCIFEROL TO TREAT AND/OR PREVENT UTERINE FIBROIDS OR POLYCYSTIC OVARY SYNDROME 审中-公开

公开(公告)号：US20240293337A1

公开(公告)日：2024-09-05

申请号：US18592394

申请日：2024-02-29

申请人： The University of Chicago

发明人： Ayman Al-Hendy , Ana Corachán , Hang-Soo Park

IPC分类号： A61K31/047

CPC分类号： A61K31/047

摘要： In aspects, the present disclosure provides a method of treating or preventing uterine fibroids (UF) or polycystic ovary syndrome (PCOS) in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of doxercalciferol. In aspects, the present disclosure provides a method of treating insulin resistance, infertility, obesity, and/or hyperandrogenism related to PCOS in a female mammal.

3.

发明申请
Inhibition of BRD Proteins Suppresses the Phenotype of Uterine Fibroids 有权

公开(公告)号：US20230122797A1

公开(公告)日：2023-04-20

申请号：US17968403

申请日：2022-10-18

申请人： The University of Chicago

发明人： Qiwei Yang , Ayman Al-Hendy

IPC分类号： A61K31/551 , A61K31/437 , A61K31/4365 , A61P15/00

摘要： In aspects, the present disclosure provides a method of treating or preventing a uterine fibroid in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an inhibitor of bromodomain (BRD) protein.

4.

发明公开
USE OF BROMODOMAIN-CONTAINING PROTEIN 9 INHIBITORS TO TREAT AND/OR PREVENT UTERINE LEIOMYOSARCOMA 审中-公开

公开(公告)号：US20240000787A1

公开(公告)日：2024-01-04

申请号：US18345461

申请日：2023-06-30

申请人： The University of Chicago

发明人： Qiwei Yang , Ayman Al-Hendy

IPC分类号： A61K31/519

CPC分类号： A61K31/519

摘要： In aspects, the present disclosure provides a method of treating or preventing a uterine leiomyosarcoma in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an inhibitor of bromodomain-containing protein 9 (BRD9).

5.

发明申请
N6-Methyladenosine Regulators in Uterine Fibroids 有权

公开(公告)号：US20230123265A1

公开(公告)日：2023-04-20

申请号：US17968386

申请日：2022-10-18

申请人： The University of Chicago

发明人： Qiwei Yang , Ayman Al-Hendy

IPC分类号： A61K31/519 , A61K35/768 , A61K38/45 , A61K38/44 , A61P35/00 , C12N15/113

摘要： In aspects, the present disclosure provides a method of treating or preventing a uterine fibroid in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an agent that modulates an N6-methyladenosine (m6A) regulator.