专利检索 ap:("The University of Chicago" OR "The United States of America,as Represented by the Secretary, Department of Health AND Human Servic" OR "President AND Fellows of Harvard College" OR "IIT Research Institute" OR "Beth Israel Deaconess Medical Center, Inc." OR "REGENTS OF THE UNIVERSITY OF MINNESOTA" OR "THE TRUSTEES OF PURDUE UNIVERSITY") AND inv:"Julian SOLWAY" 第 1 页

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发明申请
REMODILINS FOR AIRWAY REMODELING AND ORGAN FIBROSIS 有权

公开(公告)号：US20220177422A1

公开(公告)日：2022-06-09

申请号：US17594086

申请日：2020-04-02

申请人： The University of Chicago , The United States of America,as Represented by the Secretary, Department of Health and Human Servic , President and Fellows of Harvard College , IIT Research Institute , Beth Israel Deaconess Medical Center, Inc. , REGENTS OF THE UNIVERSITY OF MINNESOTA , THE TRUSTEES OF PURDUE UNIVERSITY

发明人： Julian SOLWAY , Nickolai DULIN , Diane Luci , David MALONEY , Chan Young PARK , Jeffrey FREDBERG , David MCCORMICK , Ramaswamy KRISHNAN

IPC分类号： C07C311/46 , C07D207/48 , C07D211/96 , C07D277/52 , C07D295/26 , A61P11/00

摘要： Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.