专利检索 ap:("The University of Melbourne" OR "Olivia Newton-John Cancer Research Institute" OR "CSL INNOVATION PTY LTD") AND inv:"Thomas Samuel FULFORD" 第 1 页

1.

发明申请
METHOD OF INHIBITING OR ACTIVATING GAMMA DELTA T CELLS 有权

公开(公告)号：US20220273713A1

公开(公告)日：2022-09-01

申请号：US17622563

申请日：2020-06-26

申请人： The University of Melbourne , Olivia Newton-John Cancer Research Institute , CSL INNOVATION PTY LTD

发明人： Andreas BEHREN , Jonathan CEBON , Marc Rigau CORTAL , Thomas Samuel FULFORD , Dale Ian GODFREY , Andrew HAMMET , Simone OSTROUSKA , Con PANOUSIS , Adam Peter ULDRICH

IPC分类号： A61K35/17 , C07K16/28 , C07K14/725 , A61P31/00 , A61P35/00 , A61P37/00

摘要： The present disclosure relates to methods for inhibiting activation of γδ T cells that express a Vγ9+ TCR in a subject by administering a BTN2A1 antagonist to a subject as well as methods for inducing or enhancing γδ T cells that express a Vγ9+ TCR in a subject by administering a BTN2A1 antagonist to a subject. The disclosure additionally relates to BTN2A1 antagonists and BTN2A1 agonists.