公开(公告)号：US09408822B2

公开(公告)日：2016-08-09

申请号：US14675773

申请日：2015-04-01

申请人： The University of Mississippi

发明人： Mahmoud A. Elsohly ,  Waseem Gul ,  Mohammad Khalid Ashfaq ,  Susan P. Manly

IPC分类号： A61K31/222 ,  A61K31/225 ,  C07C67/08 ,  C07C67/14 ,  C07C229/08 ,  C07C237/12 ,  C07D209/12 ,  A61K31/216

CPC分类号： A61K31/225 ,  A61K31/216 ,  A61K31/222 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

摘要： The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

摘要翻译： 在一个或多个实施方案中，本发明包含作为预防和/或预防和/或治疗的组合物的3-正十五烷基儿茶酚的水溶性衍生物（毒藤黄素饱和同系物）和/或3-正十七烷基邻苯二酚（毒性橡木漆酚饱和同系物） 或预防性治疗由毒藤和毒橡胶引起的接触性皮炎。 本发明还涉及制备这些化合物的方法。 公开的是对抗生素和银杏科植物的植物中含有抗变应原的受试者有效的化合物，其包含将包含在人中的哺乳动物（包括人）的通式（I）的通式（I）的水溶性漆酚酚酯包埋在阿卡尼亚科植物中的变应原 并且通过施用含有至少一种水溶性漆酚酯化合物的组合物来获得银杏科。

公开(公告)号：US09029417B2

公开(公告)日：2015-05-12

申请号：US13860861

申请日：2013-04-11

申请人： The University of Mississippi

发明人： Mahmoud A. Elsohly ,  Waseem Gul ,  Mohammad Khalid Ashfaq ,  Susan P. Manly

IPC分类号： A61K31/215 ,  C07D205/00 ,  C07D209/12 ,  A61K31/222 ,  A61K31/225 ,  C07C229/08 ,  C07C237/12

CPC分类号： A61K31/225 ,  A61K31/216 ,  A61K31/222 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

摘要： The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

摘要翻译： 在一个或多个实施方案中，本发明包含作为预防和/或预防和/或治疗的组合物的3-正十五烷基儿茶酚的水溶性衍生物（毒藤黄素饱和同系物）和/或3-正十七烷基邻苯二酚（毒性橡木漆酚饱和同系物） 或预防性治疗由毒藤和毒橡胶引起的接触性皮炎。 本发明还涉及制备这些化合物的方法。 本发明公开了一种能够使受试者抵抗包括在通用（I）的通式（I）的水溶性漆酚的植物中含有的变应原的受试者的化合物，所述水溶性漆酚包含人类对包含在植物中的阿卡非菌属植物中包含的变应原 并且通过施用含有至少一种水溶性漆酚酯化合物的组合物来获得银杏科。

公开(公告)号：US20130303582A1

公开(公告)日：2013-11-14

申请号：US13860861

申请日：2013-04-11

申请人： The University of Mississippi

发明人： Mahmoud A. Elsohly ,  Waseem Gul ,  Mohammad Khalid Ashfaq ,  Susan P. Manly

IPC分类号： C07D209/12 ,  C07C237/12 ,  C07C229/08

CPC分类号： A61K31/225 ,  A61K31/216 ,  A61K31/222 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

摘要： The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

摘要翻译： 在一个或多个实施方案中，本发明包含作为预防和/或预防和/或治疗的组合物的3-正十五烷基儿茶酚的水溶性衍生物（毒藤黄素饱和同系物）和/或3-正十七烷基邻苯二酚（毒性橡木漆酚饱和同系物） 或预防性治疗由毒藤和毒橡胶引起的接触性皮炎。 本发明还涉及制备这些化合物的方法。 公开的是对抗生素和银杏科的植物中含有抗变应原的受试者有效的化合物，其包含通式（I）的水溶性漆酚醛酸酯包括人类对包括人类在内的耐热和脱敏哺乳动物包括在植物中的过敏原 并且通过施用含有至少一种水溶性漆酚酯化合物的组合物来获得银杏科。

公开(公告)号：US10322103B2

公开(公告)日：2019-06-18

申请号：US15563597

申请日：2016-01-12

申请人： The University of Mississippi

发明人： Mahmoud Elsohly ,  Waseem Gul ,  Mohammad Khalid Ashfaq

IPC分类号： A61K31/216 ,  A61K31/222 ,  A61K31/225 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

摘要： The present invention, in one or more embodiments, comprises derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecyl catechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising urushiol esters of general formula (IA) [Formula should be entered here] tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a formulation containing at least one urushiol ester compound.

公开(公告)号：US09630941B2

公开(公告)日：2017-04-25

申请号：US14462482

申请日：2014-08-18

申请人： The University of Mississippi

发明人： Mahmoud A. Elsohly ,  Waseem Gul ,  Michael A. Repka ,  Soumyajit Majumdar ,  Mohammad Khalid Ashfaq

IPC分类号： A61K38/00 ,  C07D311/80 ,  C07D405/12 ,  A61K9/00 ,  A61K9/02 ,  A61K47/48

CPC分类号： C07D311/80 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/006 ,  A61K9/02 ,  A61K47/542 ,  C07D405/12

摘要： Suppository, hot melt and ophthalmic formulations containing amino esters of the formulae (I), (II) and (III), where R1, R2 and R3 are residues of amino acids such as, but not limited to, valine, sarcosine, leucine, glutamine, tryptophan, tyrosine, alanine and 4(4-aminophenyl)butyric acid or combination thereof, and salts thereof.