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17 条记录 (耗时 0.023 秒)

    Compositions for prevention/prophylactic treatment of poison ivy dermatitis
    1.
    发明授权
    Compositions for prevention/prophylactic treatment of poison ivy dermatitis 有权

    公开(公告)号：US10322103B2

    公开(公告)日：2019-06-18

    申请号：US15563597

    申请日：2016-01-12

    申请人： The University of Mississippi

    发明人： Mahmoud Elsohly ,  Waseem Gul ,  Mohammad Khalid Ashfaq

    IPC分类号： A61K31/216 ,  A61K31/222 ,  A61K31/225 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

    摘要： The present invention, in one or more embodiments, comprises derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecyl catechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising urushiol esters of general formula (IA) [Formula should be entered here] tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a formulation containing at least one urushiol ester compound.

    Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
    7.
    发明申请
    Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis 有权
    预防/预防性治疗毒性常春藤皮炎的组合物

    公开(公告)号：US20150202176A1

    公开(公告)日：2015-07-23

    申请号：US14675773

    申请日：2015-04-01

    申请人： The University of Mississippi

    发明人： Mahmoud A. ELSOHLY ,  Waseem GUL ,  Mohammad Khalid ASHFAQ ,  Susan P. MANLY

    IPC分类号： A61K31/225 ,  A61K31/216

    CPC分类号： A61K31/225 ,  A61K31/216 ,  A61K31/222 ,  C07C229/08 ,  C07C229/36 ,  C07C229/42 ,  C07C237/04 ,  C07C237/12 ,  C07D209/12

    摘要： The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

    摘要翻译： 在一个或多个实施方案中，本发明包含作为预防和/或预防和/或治疗的组合物的3-正十五烷基儿茶酚的水溶性衍生物（毒藤黄素饱和同系物）和/或3-正十七烷基邻苯二酚（毒性橡木漆酚饱和同系物） 或预防性治疗由毒藤和毒橡胶引起的接触性皮炎。 本发明还涉及制备这些化合物的方法。 公开的是对抗生素和银杏科植物的植物中含有抗变应原的受试者有效的化合物，其包含将包含在人中的哺乳动物（包括人）的通式（I）的通式（I）的水溶性漆酚酚酯包埋在阿卡尼亚科植物中的变应原 并且通过施用含有至少一种水溶性漆酚酯化合物的组合物来获得银杏科。

    Methods for stabilization and renaturation of proteins using nucleolar protein B23
    8.
    发明申请
    Methods for stabilization and renaturation of proteins using nucleolar protein B23 审中-公开
    使用核仁蛋白B23稳定和复性蛋白质的方法

    公开(公告)号：US20020115169A1

    公开(公告)日：2002-08-22

    申请号：US10100745

    申请日：2002-03-18

    申请人： The University of Mississippi Medical Center

    发明人： Mark Olson ,  Atilla Szebeni

    IPC分类号： C12P021/06 ,  C12N015/09 ,  C12P021/04 ,  C12N009/00 ,  C12N009/96

    CPC分类号： C12N9/96

    摘要： The present invention provides methods for stabilizing proteins, preventing protein aggregation, renaturation of previously-denatured proteins, reactivating a protein that has been inactivated by denaturation, preserving enzyme activities under conditions of elevated temperatures, inducing thermotolerance in bacteria, increasing the temperature optimum for the activity of an enzyme, and preventing formation of inclusion bodies by bacterially-expressed recombinant proteins.

    摘要翻译： 本发明提供了稳定蛋白质的方法，防止蛋白质聚集，先前变性蛋白质的复性，使已变性失活的蛋白质再活化，在升高的温度条件下保存酶活性，诱导细菌耐热性，增加最佳的温度 酶的活性，并且通过细菌表达的重组蛋白阻止包涵体的形成。

    HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS
    9.
    发明申请
    HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS 审中-公开
    高选择性SIGMA受体配体

    公开(公告)号：US20150018339A1

    公开(公告)日：2015-01-15

    申请号：US14187035

    申请日：2014-02-21

    申请人： THE UNIVERSITY OF MISSISSIPPI ,  I'UNIVERSITE CATHOLIQUE DE LOUVAIN ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

    发明人： Christopher R. MCCURDY ,  Christophe Mesangeau ,  Bonnie Ann Avery ,  Ahmed Hassan Amin Abdelazeem ,  Frederick T. Chin ,  Jacques Henri Poupaert

    IPC分类号： C07D277/68 ,  C07D413/06 ,  C07D417/06 ,  C07D265/36 ,  C07D491/107 ,  C07D401/06 ,  C07D235/26 ,  C07D209/08 ,  C07D263/58 ,  C07D413/12

    CPC分类号： C07D277/68 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/26 ,  C07D263/58 ,  C07D265/36 ,  C07D277/70 ,  C07D279/16 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D491/107 ,  C07D491/12

    摘要： Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls; “n” can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging R1 and N can be a substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C3-C5 cycloalkyl group, aromatic, and hetercocyclic group; wherein X′ is halogen, or C1-C4 haloalyl; wherein the Rx is a C1-C5 straight chain or branched chain alkyl or a C1-C4 straight chain or branched chain haloalkyl.

    摘要翻译： 具有通式II，III或IV的化合物，其中R 1可以是任选取代的C-4至C-7N-杂环的基团或任选取代的环状或无环叔胺或异吲哚啉-1,3- 二硫化物：R2,3,4,5,6可以各自独立地是以下部分的任何一种或组合，氰基，硝基，酰基，烷基，酰氨基，叠氮基，异硫氰酸酯，异氰酸酯，任选取代的苯胺基，卤素，醚，磺酰胺 ，硫代酰基，硝基，芳族，杂环，烯属，乙炔，氘或氚; Y可以是CH，CH 2，O，S，OCH 2，N-R，N-Ar，C-R，C-Ar; Z可以是H，O，S，S-R或NR。 R基团可以是H，芳基，烷基或环烷基; “n”可以是长度为1至5个碳原子，立体异构体，功能类似物和其药学上可接受的盐，并且其中桥接R 1和N的部分可以是取代的亚烷基，任选取代的亚烯基或任选取代的亚炔基，并且其中亚烷基可以包括 插入的C 3 -C 5环烷基，芳族和杂环基团; 其中X'是卤素，或C 1 -C 4卤代芳基; 其中Rx是C1-C5直链或支链烷基或C1-C4直链或支链卤代烷基。