公开(公告)号：US20220120745A1

公开(公告)日：2022-04-21

申请号：US17458958

申请日：2021-08-27

申请人： The University of Queensland ,  Seattle Children's Hospital dba Seattle Children's Research Institute

发明人： Yadveer Grewal ,  Gerard A. Cangelosi ,  Muhammad J.A. Shiddiky ,  Matt Trau

IPC分类号： G01N33/566 ,  G01N33/543 ,  G01N33/569

摘要： The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.

公开(公告)号：US20150377880A1

公开(公告)日：2015-12-31

申请号：US14650851

申请日：2013-12-10

申请人： THE UNIVERSITY OF QUEENSLAND ,  SEATTLE BIOMEDICAL RESEARCH INSTITUTE

发明人： Yadveer Grewal ,  Gerard A. Cangelosi ,  Muhammad J.A. Shiddiky ,  Matt Trau

IPC分类号： G01N33/566 ,  G01N33/569

CPC分类号： G01N33/566 ,  G01N33/5432 ,  G01N33/5438 ,  G01N33/56911 ,  G01N33/56961 ,  G01N33/56966 ,  G01N33/56983

摘要： The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.

摘要翻译： 本公开涉及包含生物颗粒片段和至少一种异源抗原结合分子的生物片段组合物。 在一些实施方案中，生物片段通常衍生自在表面表达至少一种异源抗原结合分子的较大的完整生物颗粒，并且生物片段具有增加的溶解度以促进抗原检测的测定。 本公开还涉及使用和制备生物片段组合物的相关方法以及实施生物片段组合物的系统和装置。 在一些实施方案中，相关方法，系统和装置不需要额外的检测试剂，例如动物衍生的检测抗体。