公开(公告)号：US20230293782A1

公开(公告)日：2023-09-21

申请号：US18017583

申请日：2021-07-30

Applicant: Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

Inventor： Taichi ITO ,  Seiichi OHTA ,  Kiyoshi HASEGAWA ,  Mitsuko ISAJI ,  Daichi TANAKA

IPC: A61L31/04 ,  A61L31/14

CPC classification number: A61L31/042 ,  A61L31/14

Abstract: A material for preventing adhesion having a high adhesion preventing effect has been desired. Provided is a sheet-like material for preventing adhesion which contains alginate, at least a portion of which is crosslinked with a curing agent, the material for preventing adhesion satisfying (1) and (2) when a dissolution test is performed in which a sample cut into a substantial circle having a diameter of 8 mm is left to stand, via a mesh, on agar of a petri dish to which a physiological saline solution is added substantially to a top surface of the agar, the petri dish is shaken at an amplitude of 25 mm and 40 shakes/min., and the weight of the sample is measured at least one arbitrary point in time. (1) The time required for the weight of the sample to be less than 0.01 g is 5-36 hours from a start of the test, and (2) the time required for the weight of the sample to reach the maximum weight is 10 hours or less from the start of the test.

公开(公告)号：US20250032681A1

公开(公告)日：2025-01-30

申请号：US18903674

申请日：2024-10-01

Applicant: Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

Inventor： Taichi ITO ,  Seiichi OHTA ,  Kiyoshi HASEGAWA ,  Mitsuko ISAJI ,  Satoshi SHIMIZU ,  Daichi TANAKA

IPC: A61L31/14 ,  A61L31/04

Abstract: The purpose of this invention is to provide an anti-adhesion material having a high anti-adhesion effect, pertaining to an anti-adhesion material comprising a biocompatible sponge-like layered body having a sponge-like first layer and a sponge-like second layer both being at least partially crosslinked with a curing agent and comprising a low endotoxin monovalent metal salt of alginic acid. The monovalent metal salt of alginic acid in the first layer has a weight average molecular weight of 30000 to 300000. The monovalent metal salt of alginic acid in the second layer has a weight average molecular weight of 1000 to 200000. The weight average molecular weights are determined by GPC-MALS after a de-crosslinking treatment. The weight average molecular weight of the monovalent metal salt of alginic acid in the first layer is higher than the weight average molecular weight of the monovalent metal salt of alginic acid in the second layer.

公开(公告)号：US20240201189A1

公开(公告)日：2024-06-20

申请号：US18286291

申请日：2022-04-12

Applicant: The University of Tokyo

Inventor： Yasuteru URANO ,  Mako KAMIYA ,  Kiyoshi HASEGAWA ,  Takeaki ISHIZAWA ,  Ryugen TAKAHASHI

IPC: G01N33/574 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

CPC classification number: G01N33/57438 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06113 ,  C07K5/06165 ,  G01N33/57492

Abstract: [Problem] To provide a fluorescent probe capable of detecting pancreatic cancer specifically.
[Solution] A fluorescent probe for use in the detection of pancreatic cancer, which comprises a compound represented by general formula (I) or a salt thereof.