公开(公告)号：US20230356169A1

公开(公告)日：2023-11-09

申请号：US18223343

申请日：2023-07-18

Applicant: TheTrustees of Princeton University

Inventor： Robert K. PRUD'HOMME ,  Robert F. Pagels ,  Chester E. Markwalter

IPC: B01J13/02 ,  C08J3/21 ,  C08J3/215 ,  C08J3/22 ,  B01J13/22 ,  C08G81/02 ,  B01J13/14

CPC classification number: B01J13/025 ,  C08J3/212 ,  C08J3/215 ,  C08J3/226 ,  B01J13/22 ,  C08G81/025 ,  C08G81/027 ,  B01J13/14 ,  B82Y40/00

Abstract: A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.