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    Attenuation of fibroblast proliferation
    4.
    发明授权
    Attenuation of fibroblast proliferation 失效
    成纤维细胞增殖的衰减

    公开(公告)号：US07056711B2

    公开(公告)日：2006-06-06

    申请号：US09727873

    申请日：2000-12-01

    申请人： Elizabeth M. Denholm ,  Elizabeth Cauchon ,  Paul J. Silver

    发明人： Elizabeth M. Denholm ,  Elizabeth Cauchon ,  Paul J. Silver

    IPC分类号： C12N9/00

    CPC分类号： A61K38/51 ,  C12Y402/02019

    摘要： Highly purified and specific glycosaminoglycan degrading enzymes, chondroitinase B and chondroitinase AC, are used to treat fibroproliferative diseases. The enzymatic removal of chondroitin sulfate B(dermatan sulfate), and to a lesser extent, chondroitin sulfate A or C, from cell surfaces effectively decreases growth factor receptors on the cells and thereby decreases the cell proliferative response to such growth factors. In addition, removal of chondroitin sulfates reduces secretion of collagen, one of the major extracellular matrix components. Through the combined inhibition of fibroblast proliferation and collagen synthesis, treatment with chondroitinase B or chondroitinase AC decreases the size of fibrous tissue found in psoriasis, scleroderma, keloids, pulmonary fibrosis and surgical adhesions.

    摘要翻译： 高纯度和特异性的糖胺聚糖降解酶，软骨素酶B和软骨素酶AC用于治疗纤维增生性疾病。 从细胞表面去除硫酸软骨素B（硫酸皮肤素），并且在较小程度上去除硫酸软骨素A或C有效地降低细胞上的生长因子受体，从而降低对这种生长因子的细胞增殖反应。 此外，去除硫酸软骨素减少胶原蛋白的分泌，胶原蛋白是主要的细胞外基质成分之一。 通过组合抑制成纤维细胞增殖和胶原合成，用软骨素酶B或软骨素酶AC治疗可以减少牛皮癣，硬皮病，瘢痕疙瘩，肺纤维化和手术粘连中发现的纤维组织的大小。

    Attenuation of tumor growth, metastasis and angiogenesis
    5.
    发明授权
    Attenuation of tumor growth, metastasis and angiogenesis 失效
    肿瘤生长，转移和血管生成的衰减

    公开(公告)号：US06979563B1

    公开(公告)日：2005-12-27

    申请号：US09715965

    申请日：2000-11-17

    申请人： Elizabeth M. Denholm ,  Yong-Qing Lin ,  Paul J. Silver

    发明人： Elizabeth M. Denholm ,  Yong-Qing Lin ,  Paul J. Silver

    IPC分类号： A61K38/51 ,  C12N9/00

    CPC分类号： A61K38/51

    摘要： A highly purified and specific glycosaminoglycan degrading enzyme, chondroitinase AC, and to a lesser extent, chondroitinase B, can be used in the treatment of metastatic cancers and in other disorders characterized by angiogenesis. The enzymatic removal of chondroitin sulfates A and C, and to a lesser extent, chondroitin sulfate B, from cell surfaces directly decreases the ability of tumor cells to invade blood vessels and thus prevents the formation of metastatic, or secondary tumors; inhibits tumor cell growth; and decreases angiogenesis by inhibiting both endothelial cell proliferation and capillary formation. Decreasing the formation of new blood vessels into the tumor in turn decreases the potential for tumor growth, and further decreases the ability of tumor cells to invade the bloodstream. These effects are opposite to the prometastatic effects of tumor-secreted heparanase.

    摘要翻译： 高度纯化和特异性的糖胺聚糖降解酶，软骨素酶AC和较小程度的软骨素酶B可用于治疗转移性癌症和其它以血管生成为特征的疾病。 来自细胞表面的硫酸软骨素A和C以及较低程度的硫酸软骨素酶的酶促去除直接降低肿瘤细胞侵入血管的能力，从而防止转移性或继发性肿瘤的形成; 抑制肿瘤细胞生长; 并通过抑制内皮细胞增殖和毛细血管形成来减少血管生成。 减少肿瘤新血管的形成反过来降低了肿瘤生长的可能性，进一步降低了肿瘤细胞侵入血液的能力。 这些作用与肿瘤分泌型肝素酶的前体作用相反。