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    5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles
    3.
    发明授权
    5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles 失效
    5- [3 - [[2-喹啉基]甲氧基]苯基] -1,3-恶唑

    公开(公告)号：US4681940A

    公开(公告)日：1987-07-21

    申请号：US799673

    申请日：1985-11-19

    Applicant: John H. Musser ,  Reinhold H. W. Bender

    Inventor： John H. Musser ,  Reinhold H. W. Bender

    IPC: C12N9/99 ,  A61K31/42 ,  A61K31/425 ,  A61K31/47 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D263/14 ,  C07D263/24 ,  C07D333/00 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

    CPC classification number: C07D417/12 ,  C07D263/14 ,  C07D263/24 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14

    Abstract: There are disclosed compounds of the formula ##STR1## wherein X is N or CR.sup.2Y is O, S, NR.sup.2, CHR.sup.2 or C(R.sup.2).sub.2 when n=0, or N or CR.sup.2 when n=1;p is 0-3;R.sup.1 is ##STR2## R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen, lower alkyl, phenyl, thienyl, furyl, pyridyl, ##STR3## --C(R.sup.4).sub.3 or --(CH.sub.2).sub.p COOR.sup.2 ; R.sup.4 is halo;Z is O or S;and the pharmaceutically acceptable salts thereof, and their use in the treatment of luekotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.

    Abstract translation: 当n = 0时，公开了下式的化合物，其中当n = 0时，X是N或CR 2 Y是O，S，NR 2，CHR 2或C（R 2）2，或当n = 1时，N或CR 2; p为0-3; R1是氢或低级烷基; R3是氢，低级烷基，苯基，噻吩基，呋喃基，吡啶基，-C（R4）3或 - （CH2）pCOOR2; R4是卤素; Z是O或S; 及其药学上可接受的盐，以及它们在治疗牛皮癣，溃疡性结肠炎，类风湿性关节炎以及其他立即治疗氯代三烯介导的鼻支气管阻塞性空气通道病症如过敏性鼻炎，过敏性支气管哮喘等中的用途 超敏反应。

    2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
    5.
    发明授权
    2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents 失效
    2-芳基取代的杂环化合物作为抗过敏和抗炎药

    公开(公告)号：US4895953A

    公开(公告)日：1990-01-23

    申请号：US311011

    申请日：1989-02-15

    Applicant: John H. Musser ,  Reinhold H. W. Bender ,  Anthony F. Kreft, III

    Inventor： John H. Musser ,  Reinhold H. W. Bender ,  Anthony F. Kreft, III

    IPC: C07D213/30 ,  C07D263/32 ,  C07D277/24 ,  C07D277/30 ,  C07D413/12 ,  C07D417/12

    CPC classification number: C07D213/30 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D417/12

    Abstract: There are disclosed compounds of the formula ##STR1## wherein ##STR2## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 ##STR3## W represents a bond or --O--, --S-- or ##STR4## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR5## R.sup.6 is hydrogen, lower alkyl, --COOR.sup.4 or ##STR6## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.

    Abstract translation: 公开了下式的化合物，其中 n是0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3表示键或-O - ， - S-或m表示1-15; R4是氢或低级烷基; R5是低级烷基，一氟低烷基，二氟低级烷基，聚氟低烷基，全氟低级烷基或R6是氢，低级烷基，-COOR4或其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管梗阻 空气通道条件，如过敏性鼻炎，过敏性支气管哮喘等，以及抗炎药。

    Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propano ic acid derivatives
    10.
    发明授权
    Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propano ic acid derivatives 失效
    某些3,3' - [[[（2-苯基-4-噻唑基）甲氧基]苯基]亚甲基]二硫代双 - 丙酸衍生物

    公开(公告)号：US5103014A

    公开(公告)日：1992-04-07

    申请号：US525418

    申请日：1990-05-18

    Applicant: John H. Musser ,  Reinhold H. W. Bender ,  Anthony F. Kreft, III ,  James A. Nelson

    Inventor： John H. Musser ,  Reinhold H. W. Bender ,  Anthony F. Kreft, III ,  James A. Nelson

    IPC: C07D213/30 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D417/12

    CPC classification number: C07D213/30 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D417/12

    Abstract: There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is --(CH.sub.2).sub.n O--, --(CH.sub.2).sub.n S--, ##STR4## R.sup.1 is ##STR5## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;R.sup.3 is ##STR6## W represents a bond or --O--, --S-- or ##STR7## m is 1-15; R.sup.4 is hydrogen or loweralkyl;R.sup.5 is lower alkyl, monofluoroloweralkyl, difluroloweralkyl, polyfluroloweralkyl, perfluoroloweralkyl or ##STR8## R.sup.6 is hydrogen lower alkyl, --COOR.sup.4 or ##STR9## R.sup.7 is OR.sup.4 or N(R.sup.4).sub.2 ; R.sup.8 is OR.sup.4 or N(R.sup.4).sub.2 ;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstruction airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, as antiinflammatory agents.

    Abstract translation: 公开了下式的化合物，其中X是Y，Z是 - （CH 2）n O-， - （CH 2）n -S-， R 1是 n为0-5; R2是氢，低级烷基，低级烷氧基，低级烷氧基羰基，三氟甲基，硝基，氰基或卤素; R3表示W表示键或-O - ， - S-或m表示1-15; R4是氢或低级烷基; R 5是低级烷基，一氟代低级烷基，二氟氟烷基，聚芴基烷基，全氟低级烷基或R 6是氢低级烷基，-COOR 4或者R 7是OR 4或N（R 4）2; R8为OR4或N（R4）2; 及其药学上可接受的盐，以及它们在治疗白三烯介导的鼻支气管阻塞空气通道条件（例如过敏性鼻炎，过敏性支气管哮喘等）中作为抗炎剂的用途。

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