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公开(公告)号：US12036293B2
公开(公告)日：2024-07-16
申请号：US17154926
申请日：2021-01-21
发明人： Philip Blower , Gregory Mullen
IPC分类号： A61K51/04 , A61B5/00 , A61K51/08 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
CPC分类号： A61K51/0478 , A61B5/0035 , A61K51/082 , A61K51/088 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
摘要： A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
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公开(公告)号：US12109277B2
公开(公告)日：2024-10-08
申请号：US18499758
申请日：2023-11-01
发明人： Philip Blower , Gregory Mullen
IPC分类号： A61K51/04 , A61B5/00 , A61K51/08 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
CPC分类号： A61K51/0478 , A61B5/0035 , A61K51/082 , A61K51/088 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
摘要： A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
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公开(公告)号：US20240165277A1
公开(公告)日：2024-05-23
申请号：US18499758
申请日：2023-11-01
发明人： Philip Blower , Gregory Mullen
IPC分类号： A61K51/04 , A61B5/00 , A61K51/08 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
CPC分类号： A61K51/0478 , A61B5/0035 , A61K51/082 , A61K51/088 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
摘要： A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
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公开(公告)号：US11826436B2
公开(公告)日：2023-11-28
申请号：US17857990
申请日：2022-07-05
发明人： Philip Blower , Gregory Mullen
IPC分类号： A61K51/04 , A61P35/00 , A61B5/00 , A61K51/08 , C07B59/00 , C01G15/00 , C07C251/24 , C07F5/00
CPC分类号： A61K51/0478 , A61B5/0035 , A61K51/082 , A61K51/088 , A61P35/00 , C01G15/00 , C07B59/00 , C07C251/24 , C07F5/00
摘要： A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
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