公开(公告)号：US20090318786A1

公开(公告)日：2009-12-24

申请号：US12110183

申请日：2008-04-25

申请人： Thomas B. BLANK ,  Timothy L. RUCHTI ,  Stephen L. MONFRE ,  Kevin H. HAZEN ,  Sedar BROWN ,  Christopher SLAWINSKI

发明人： Thomas B. BLANK ,  Timothy L. RUCHTI ,  Stephen L. MONFRE ,  Kevin H. HAZEN ,  Sedar BROWN ,  Christopher SLAWINSKI

IPC分类号： A61B5/1455

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/146

摘要： Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.

摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 更具体地，使用受控流体输送到样品探针的尖端和组织测量部位之间的区域来控制取样。 受控的流体输送增强了皮肤样品位点与薄层流体的覆盖。 在空间传送，体积，厚度，分布，温度和/或压力方面控制接触流体的传送。

公开(公告)号：US20080146899A1

公开(公告)日：2008-06-19

申请号：US12027934

申请日：2008-02-07

申请人： Timothy L. RUCHTI ,  Kevin H. Hazen ,  Thomas B. Blank

发明人： Timothy L. RUCHTI ,  Kevin H. Hazen ,  Thomas B. Blank

IPC分类号： A61B5/1455

CPC分类号： G01N21/274 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/359

摘要： A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.

摘要翻译： 提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。 更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。 在另一个实施例中，引导件用于相对于皮肤组织取样部位显着减少样本探针放置的变化，从而产生使用参考分析物浓度来维持校准性能的能力，有或没有使用参考 频谱在时间附近收集。

公开(公告)号：US20080319299A1

公开(公告)日：2008-12-25

申请号：US12125017

申请日：2008-05-21

申请人： Timothy W. STIPPICK ,  Thomas B. BLANK ,  Timothy L. RUCHTI ,  Christopher SLAWINSKI

发明人： Timothy W. STIPPICK ,  Thomas B. BLANK ,  Timothy L. RUCHTI ,  Christopher SLAWINSKI

IPC分类号： A61B5/055

CPC分类号： A61B5/1455 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6843

摘要： The invention relates generally to a probe interface method and apparatus for use in conjunction with an optical based noninvasive analyzer. More particularly, an algorithm controls a sample probe position and attitude relative to a skin sample site before and/or during sampling. For example, a sample probe head of a sample module is controlled by an algorithm along the normal-to-skin-axis. Preferably, the sample probe head is positioned in terms of 3-D location in the x-, y-, and z-axes and is attitude orientated in terms of pitch, yaw, and roll. Further, attitude of the probe head is preferably orientated prior to contact of the sample probe head with the tissue sample using indicators, such as non-contact distance feedback from capacitance sensor, contacting or non-contacting optical sensors, and/or contact electrical sensors.

摘要翻译： 本发明一般涉及与光学非侵入式分析仪结合使用的探针接口方法和装置。 更具体地，算法在采样之前和/或采样期间相对于皮肤样品位置控制样品探针位置和姿态。 例如，样本模块的样本探针头沿着正常到皮肤轴的算法来控制。 优选地，样品探头位于x-，y-和z-轴上的3-D位置，并且以沥青，偏转和辊的方式取向。 此外，探针头的姿态优选地在样品探头与组织样本接触之前使用诸如来自电容传感器的非接触距离反馈，接触或非接触光学传感器和/或接触电传感器 。