公开(公告)号：US20060058479A1

公开(公告)日：2006-03-16

申请号：US10527227

申请日：2003-09-05

申请人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Guenter Malsch ,  James McNiven Courtney ,  John Gaylor ,  Mary Grant

发明人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Guenter Malsch ,  James McNiven Courtney ,  John Gaylor ,  Mary Grant

IPC分类号： C08F2/00 ,  C08F4/00

CPC分类号： B01D71/76 ,  A61M1/3489 ,  B01D71/40 ,  B01D71/42 ,  C08F220/44 ,  C08L33/14 ,  C08L33/20

摘要： The invention relates to a novel polymer composition comprising at least one copolymer constituted of acrylic (AC) monomer units and of at least one water-soluble comonomer unit, which is preferably 2-acrylamido-2-methyl-propane sulfonic acid (AMPS). The composition is used to produce materials, such as membranes, film or suface coatings, that arc suitable as highly tissue compatible supports for epithelial cells, such as hepatocytes. The materials are suitable to be used in a bioartificial liver, where they work as separating membrane and carrier for adhesion-dependent tissue cells. As an example it is described how selectively permeable membranes are formed by a phase inversion process from these acrylic copolymers with varying content of 2-aclylanido-2-methylpropane sulfonic acid (AMPS) and how they interact with liver cells to construct a biohybrid organ for liver replacement.

摘要翻译： 本发明涉及包含至少一种由丙烯酸（AC）单体单元和至少一种水溶性共聚单体单元构成的共聚物的新型聚合物组合物，其优选为2-丙烯酰胺基-2-甲基 - 丙磺酸（AMPS）。 该组合物用于生产诸如膜，膜或表面涂层的材料，其适合作为上皮细胞如肝细胞的高度组织相容的载体。 该材料适用于生物人造肝脏，其中它们作为分离膜和载体用于粘附依赖性组织细胞。 作为示例，描述了通过具有不同含量的2-丙烯酰氨基-2-甲基丙磺酸（AMPS）的这些丙烯酸共聚物的相转化方法形成选择性渗透膜的方式，以及它们如何与肝细胞相互作用以构建生物混合器官 肝脏替代