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    Method and device for treating cancer
    3.
    发明授权
    Method and device for treating cancer 有权

    公开(公告)号：US09656014B2

    公开(公告)日：2017-05-23

    申请号：US14879019

    申请日：2015-10-08

    申请人： Brian J Leberthon

    发明人： Brian J Leberthon

    IPC分类号： A61M37/00 ,  A61M1/34 ,  A61M1/36

    CPC分类号： A61M1/3486 ,  A61M1/3489 ,  A61M1/3493 ,  A61M1/3616 ,  A61M1/362 ,  A61M1/3687

    摘要： A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane wall portions that enable a molecular-sized activating agent in a carrier fluid that enhances an immune response to pass through these porous wall portions. Pore size is such to allow the molecular-sized activating agent in the interior of the chamber to enter the wells yet prevents immune cells and cancer cells in the wells to pass through the porous wall portions into the interior of the chamber. Blood is retained in the wells so that it remains in contact with the immune cells and cancer cells for a predetermined period sufficient to enhance an immune response. Then the cells with an enhanced immune response are return to the patient.

    BIOREACTOR UNIT FOR USE IN BIOARTIFICIAL KIDNEY DEVICE
    5.
    发明申请
    BIOREACTOR UNIT FOR USE IN BIOARTIFICIAL KIDNEY DEVICE 有权
    生物工程设备用于生物科技设备

    公开(公告)号：US20150076066A1

    公开(公告)日：2015-03-19

    申请号：US14395810

    申请日：2013-04-22

    申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    发明人： Daniele Zink ,  Yar Oo Zay

    IPC分类号： A61M1/34 ,  B01D63/02

    CPC分类号： A61M1/3489 ,  A61M1/3417 ,  A61M1/3434 ,  A61M1/3472 ,  B01D63/02

    摘要： There is provided a bioreactor device having cells, including human primary proximal tubule cells (HPTCs) or HPTC-like cells on the exterior surface of hollow fiber membranes included within the device. Also provided are bioartificial kidney devices incorporate the bioreactor device and methods of using such devices.

    摘要翻译： 提供了具有细胞的生物反应器装置，其包括在装置内的中空纤维膜的外表面上包括人类初级近端小管细胞（HPTC）或HPTC样细胞。 还提供了包括生物反应器装置的生物人造肾装置和使用这种装置的方法。

    Artificial kidney
    6.
    发明授权
    Artificial kidney 有权
    人造肾

    公开(公告)号：US08834400B2

    公开(公告)日：2014-09-16

    申请号：US13467562

    申请日：2012-05-09

    申请人： Franciscus Peter Houwen ,  Henk Van Middendorp ,  Jacobus Cornelis Musters

    发明人： Franciscus Peter Houwen ,  Henk Van Middendorp ,  Jacobus Cornelis Musters

    IPC分类号： A61M37/00 ,  A61M1/34 ,  A61M1/36

    CPC分类号： A61M1/3472 ,  A61M1/3468 ,  A61M1/3486 ,  A61M1/3489 ,  A61M1/3672 ,  A61M1/3675

    摘要： Artificial kidney for gradual, and at least semi-continuous, blood treatment, wherein a blood stream is fed from a body of a living human or animal being into the artificial kidney, where anticoagulation is first effected, blood cells and molecules of large and medium molecular weight, such as proteins, are then primarily separated from plasma and fed back to the blood stream, regulating a water and salt balance by diverting excess plasma water and further removing from the blood stream, plasma or plasma water accumulated and toxic substances, by removal of specific electrolytes and waste products and wherein purified or partially purified plasma and plasma water is being carried back to the blood tract of the body.

    摘要翻译： 用于逐渐和至少半连续血液处理的人造肾，其中将血流从活的人或动物的体进入人造肾，其中首先进行抗凝，血细胞和大中等分子 分子量，如蛋白质，然后主要从血浆中分离并反馈到血流，调节水和盐平衡通过转移过量的血浆水，并进一步从血流，血浆或血浆水中积累的和有毒物质， 去除特定的电解质和废物，并且其中纯化的或部分纯化的血浆和血浆水正被运送到身体的血管。

    Hepatic lobule-like bioreactor
    7.
    发明授权
    Hepatic lobule-like bioreactor 有权
    肝小叶样生物反应器

    公开(公告)号：US08735143B2

    公开(公告)日：2014-05-27

    申请号：US14005563

    申请日：2011-03-21

    申请人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

    发明人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

    IPC分类号： C12M3/00 ,  C12N5/00 ,  A61M1/14

    CPC分类号： C12N5/0062 ,  A61F2/022 ,  A61M1/14 ,  A61M1/3472 ,  A61M1/3489 ,  C12M3/00 ,  C12M21/08 ,  C12M25/10 ,  C12M25/14 ,  C12M29/26 ,  C12N5/067

    摘要： The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing.

    摘要翻译： 本发明提供了一种肝小叶状生物反应器。 生物反应器包括封装在壳体内的纳米纤维支架。 肝内纤维状血管网络，胆管毛细血管网，上肝胆管，下肝胆管，连接肝胆管上胆管和胆总管的胆总管，以及胆管毛细血管网包围肝细胞的胶原纤维微通道 纳米纤维支架。 胆管毛细血管网中的胆汁毛细管具有两个或更多个用于胆管上皮细胞的入口端口。 用于肝细胞的胶原纤维微通道设置有两个或更多个用于肝细胞的入口。 肝内血管网设置有液体入口和液体出口。 这些端口延伸穿过外壳。

    SERVICEABLE BIOREACTOR
    8.
    发明申请
    SERVICEABLE BIOREACTOR 有权
    可维修的生物工程师

    公开(公告)号：US20130333178A1

    公开(公告)日：2013-12-19

    申请号：US13863123

    申请日：2013-04-15

    申请人： UNITED ARAB EMIRATES UNIVERSITY

    发明人： Ali Abdulah Hilal-Alnaqbi ,  Abdel-Hamid Ismail Mourad

    IPC分类号： B01D65/02 ,  B01D67/00

    CPC分类号： B01D65/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3475 ,  A61M1/3489 ,  A61M1/3496 ,  A61M2205/3331 ,  B01D61/28 ,  B01D63/00 ,  B01D63/02 ,  B01D67/00 ,  B01D69/082 ,  Y10T29/49723

    摘要： The invention resides in an apparatus for treatment of a substance. The apparatus has a substance tube for enabling a substance to be treated to pass in to the substance tube via the substance-inlet and out of the substance tube through the substance-outlet. The apparatus also has a cleaning chamber, wherein the substance tube is configured in fluid communication with the cleaning chamber to enable a substance to diffuse the permeable membrane between the substance tube and the cleaning chamber such that a substance can be substantially cleaned by a cleaner, the substance comprising blood or plasma and the cleaner comprising a cell culture. The substance tube is removably connectable with the cleaning chamber for inter-changeability or serviceability. The apparatus can further comprise a support compartment configured to connect to, or enclosing, the cleaning chamber, which functions to carry a fluid to substantially maintain the functionality of the cleaner.

    摘要翻译： 本发明在于用于处理物质的装置。 该装置具有用于使物质被处理的物质管通过物质入口通过物质出口通过物质管进入物质管。 该设备还具有清洁室，其中物质管被构造成与清洁室流体连通，以使物质能够将物质管道和清洁室之间的渗透膜扩散，使得物质可以被清洁器基本上清洁， 包含血液或血浆的物质和包含细胞培养物的清洁剂。 物质管可拆卸地与清洁室连接，用于互换性或适用性。 该装置还可以包括配置成连接到清洁室或包围清洁室的支撑室，其用于承载流体以基本上保持清洁器的功能。