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公开(公告)号：US20090062200A1
公开(公告)日：2009-03-05
申请号：US12135549
申请日：2008-06-09
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US20100087632A1
公开(公告)日：2010-04-08
申请号：US12623869
申请日：2009-11-23
IPC分类号： C07K19/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 结合并抑制血管内皮生长因子（VEGF）的融合蛋白。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07972598B2
公开(公告)日：2011-07-05
申请号：US12623869
申请日：2009-11-23
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 结合并抑制血管内皮生长因子（VEGF）的融合蛋白。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07635474B2
公开(公告)日：2009-12-22
申请号：US12135549
申请日：2008-06-09
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07306799B2
公开(公告)日：2007-12-11
申请号：US11089803
申请日：2005-03-25
申请人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
发明人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
CPC分类号： C07K14/71 , A61K38/00 , A61K38/179 , C07K14/47 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
摘要翻译： 公开了具有改善的药物动力学和改善的组织穿透的修饰的嵌合多肽，其可用于治疗眼睛疾病，包括年龄相关性黄斑变性和糖尿病性视网膜病变。
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公开(公告)号：US20080220004A1
公开(公告)日：2008-09-11
申请号：US11998709
申请日：2007-11-30
申请人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
发明人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
IPC分类号： A61K39/395 , A61K38/02
CPC分类号： C07K14/71 , A61K38/00 , A61K38/179 , C07K14/47 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
摘要翻译： 公开了具有改善的药物动力学和改善的组织穿透的修饰的嵌合多肽，其可用于治疗眼睛疾病，包括年龄相关性黄斑变性和糖尿病性视网膜病变。
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公开(公告)号：US07399612B2
公开(公告)日：2008-07-15
申请号：US11346008
申请日：2006-02-02
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07279159B2
公开(公告)日：2007-10-09
申请号：US10880021
申请日：2004-06-29
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 能够结合血管内皮生长因子（VEGF）的核酸分子和多聚体蛋白质。 公开了可用于治疗VEGF相关病症和疾病的VEGF陷阱，其专门用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07521049B2
公开(公告)日：2009-04-21
申请号：US11998709
申请日：2007-11-30
申请人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
发明人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
CPC分类号： C07K14/71 , A61K38/00 , A61K38/179 , C07K14/47 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
摘要翻译： 公开了具有改善的药物动力学和改善的组织穿透的修饰的嵌合多肽，其可用于治疗眼睛疾病，包括年龄相关性黄斑变性和糖尿病性视网膜病变。
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公开(公告)号：US07303747B2
公开(公告)日：2007-12-04
申请号：US11218234
申请日：2005-09-01
申请人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
发明人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
CPC分类号： C07K14/71 , A61K38/00 , A61K38/179 , C07K14/47 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
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