公开(公告)号：US10258615B2

公开(公告)日：2019-04-16

申请号：US15103234

申请日：2014-12-09

Applicant: Thomas Jefferson University

Inventor： Davide Trotti ,  Piera Pasinelli ,  Michael R. Jablonski

IPC: A61K31/55 ,  A61K45/06 ,  A61K31/428 ,  A61K31/473 ,  A61K31/496 ,  A61K31/4725

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

公开(公告)号：US11369596B2

公开(公告)日：2022-06-28

申请号：US16289273

申请日：2019-02-28

Applicant: Thomas Jefferson University

Inventor： Davide Trotti ,  Piera Pasinelli ,  Michael R. Jablonski

IPC: A61K31/473 ,  A61K45/06 ,  A61K31/428 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

公开(公告)号：US20220362236A1

公开(公告)日：2022-11-17

申请号：US17750848

申请日：2022-05-23

Applicant: Thomas Jefferson University

Inventor： Davide Trotti ,  Piera Pasinelli ,  Michael R. Jablonski

IPC: A61K31/473 ,  A61K45/06 ,  A61K31/428 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ARC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurode generative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

公开(公告)号：US20190192503A1

公开(公告)日：2019-06-27

申请号：US16289273

申请日：2019-02-28

Applicant: Thomas Jefferson University

Inventor： Davide Trotti ,  Piera Pasinelli ,  Michael R. Jablonski

IPC: A61K31/473 ,  A61K31/55 ,  A61K31/496 ,  A61K45/06 ,  A61K31/428 ,  A61K31/4725

CPC classification number: A61K31/473 ,  A61K31/428 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.