公开(公告)号：US20100291092A1

公开(公告)日：2010-11-18

申请号：US12701149

申请日：2010-02-05

申请人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

发明人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

IPC分类号： A61K39/395 ,  C07K16/28 ,  G01N33/53 ,  A61P31/04

CPC分类号： G01N33/56911 ,  G01N33/68 ,  G01N2333/32

摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

公开(公告)号：US08192720B2

公开(公告)日：2012-06-05

申请号：US12701149

申请日：2010-02-05

申请人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

发明人： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Richard Lyons

IPC分类号： A61K49/00 ,  A61K39/07 ,  A61K39/02

CPC分类号： G01N33/56911 ,  G01N33/68 ,  G01N2333/32

摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。