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1.发明授权Compositions and methods for detection, prevention, and treatment of anthrax and other infectious diseases 有权用于检测，预防和治疗炭疽病和其他传染病的组合物和方法公开(公告)号：US07682796B2
公开(公告)日：2010-03-23
申请号：US10809831
申请日：2004-03-26
申请人： Thomas R. Kozel , William J. Murphy , Suzanne Brandt , Peter Thorkildson , Ann Percival , Bruce R. Blazar , Julie A. Lovchik , C. Rick Lyons
发明人： Thomas R. Kozel , William J. Murphy , Suzanne Brandt , Peter Thorkildson , Ann Percival , Bruce R. Blazar , Julie A. Lovchik , C. Rick Lyons
CPC分类号： G01N33/56911 , G01N33/68 , G01N2333/32
摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.
摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。
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2.发明申请COMPOSITIONS AND METHODS FOR DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES 有权用于检测，预防和治疗其他感染性疾病的组合物和方法公开(公告)号：US20090280513A1
公开(公告)日：2009-11-12
申请号：US10809831
申请日：2004-03-26
申请人： Thomas R. Kozel , William J. Murphy , Suzanne Brandt , Peter Thorkildson , Ann Percival , Bruce R. Blazar , Julie A. Lovchik , C. Rick Lyons
发明人： Thomas R. Kozel , William J. Murphy , Suzanne Brandt , Peter Thorkildson , Ann Percival , Bruce R. Blazar , Julie A. Lovchik , C. Rick Lyons
CPC分类号： G01N33/56911 , G01N33/68 , G01N2333/32
摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods of immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.
摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 在一个方面，本发明提供了针对炭疽芽孢杆菌或其他包裹的病原体免疫人或动物的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。
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公开(公告)号：US20200054721A1
公开(公告)日：2020-02-20
申请号：US16343640
申请日：2017-10-20
申请人： Bruce R. BLAZAR , John H. GRIFFIN , Ryan P. FLYNN , Ranjeet K. SINHA , Regents of the University of Minnesota , The Scripps Research Institute
摘要： This disclosure provides materials and methods for treating or preventing graft-versus-host-disease (GVHD) using protein C or activated protein C or a signaling-selective variant or mutant thereof.
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公开(公告)号：US07101542B1
公开(公告)日：2006-09-05
申请号：US09579738
申请日：2000-05-26
申请人： Daniel A. Vallera , Bruce R. Blazar
发明人： Daniel A. Vallera , Bruce R. Blazar
CPC分类号： C07K14/52 , A61K38/164 , C07K2319/00 , C12N2740/15043
摘要： The invention features vectors encoding immunotoxic fusion proteins containing targeting domains and toxic domains, targeting cells transduced with the vectors, methods of making the targeting cells, and methods of treating diseases (e.g., cancer) using both the vectors and the transduced cells.
摘要翻译： 本发明的特征在于编码含有靶向结构域和毒性结构域的免疫毒素融合蛋白的载体，靶向用载体转导的细胞，制备靶向细胞的方法，以及使用载体和转导的细胞治疗疾病（例如癌症）的方法。
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5.发明申请公开(公告)号：US20190022125A1
公开(公告)日：2019-01-24
申请号：US15757516
申请日：2016-09-02
申请人： Bruce R. Blazar , Cameron McDonald-Hyman , Michael Dustin , Sudha Kumari , Tom Neubert , James Muller , Keli Hippen
发明人： Bruce R. Blazar , Cameron McDonald-Hyman , Michael Dustin , Sudha Kumari , Tom Neubert , James Muller , Keli Hippen
IPC分类号： A61K31/7105 , A61P35/00 , C12N15/113 , A61K35/17 , C12N5/0783
摘要： Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) are provided.
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公开(公告)号：US20130101567A1
公开(公告)日：2013-04-25
申请号：US13639927
申请日：2011-03-28
申请人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
发明人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
IPC分类号： C12N5/0783
CPC分类号： C12N5/0637 , C12N2500/32 , C12N2501/04 , C12N2501/2302 , C12N2501/51 , C12N2501/515
摘要： Compositions and methods for expanding natural T regulatory cells (nTregs) without substantially sacrificing suppressive function of the cells are disclosed. Also provided are uses of the expanded nTregs for cellular therapy.
摘要翻译： 公开了用于扩增天然T调节细胞（nTreg）而不显着牺牲细胞抑制功能的组合物和方法。 还提供了扩大的nTregs用于细胞治疗的用途。
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公开(公告)号：US20120142750A1
公开(公告)日：2012-06-07
申请号：US13308060
申请日：2011-11-30
申请人： Wei Chen , Bruce R. Blazar , David Munn , Andrew Mellor
发明人： Wei Chen , Bruce R. Blazar , David Munn , Andrew Mellor
IPC分类号： A61K31/405 , A61P37/06 , A61P37/04
CPC分类号： C07D471/04 , A61K31/405 , C07D209/12 , C07D209/14 , C07D209/20 , C07D209/36 , C07D209/40 , C07D209/94 , C07D213/74 , C07D215/26 , C07D233/56 , C07D307/77 , C07D307/92 , C07D311/92 , C07D333/58 , C07D403/06 , C07D417/04 , C07D491/04 , C07D513/04
摘要： The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.
摘要翻译： 本发明提供了用于控制调节性T细胞（Treg）的产生及其用途的方法。
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公开(公告)号：US20110268752A1
公开(公告)日：2011-11-03
申请号：US12999926
申请日：2009-06-19
申请人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
发明人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
IPC分类号： A61K35/14 , A61P37/06 , C12N5/0783
CPC分类号： A61K39/0008 , A61K39/001 , A61K2035/122 , A61K2039/5158 , C12N5/0636 , C12N5/0638 , C12N2501/065 , C12N2501/70 , C12N2501/999
摘要： The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
摘要翻译： 本发明提供了将非Treg转化为Treg的方法和组合物。 转化的Treg被称为可诱导Treg（iTreg）。 iTregs可用于预防，抑制，阻断或抑制免疫应答。 例如，iTreg可用于防止人或其他动物宿主中移植组织的排斥，或防止移植物抗宿主病。 iTreg也可用于治疗自身免疫性疾病。
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9.发明申请COMPOSITIONS AND METHODS FOR DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES 有权用于检测，预防和治疗其他感染性疾病的组合物和方法公开(公告)号：US20100291092A1
公开(公告)日：2010-11-18
申请号：US12701149
申请日：2010-02-05
申请人： Thomas Kozel , William Murphy , Suzanne Brandt , Bruce R. Blazar , Julie A. Lovchik , Peter Thorkildson , Ann Percival , C. Richard Lyons
发明人： Thomas Kozel , William Murphy , Suzanne Brandt , Bruce R. Blazar , Julie A. Lovchik , Peter Thorkildson , Ann Percival , C. Richard Lyons
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53 , A61P31/04
CPC分类号： G01N33/56911 , G01N33/68 , G01N2333/32
摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.
摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。
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公开(公告)号：US09228172B2
公开(公告)日：2016-01-05
申请号：US12999926
申请日：2009-06-19
申请人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
发明人： James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
CPC分类号： A61K39/0008 , A61K39/001 , A61K2035/122 , A61K2039/5158 , C12N5/0636 , C12N5/0638 , C12N2501/065 , C12N2501/70 , C12N2501/999
摘要： The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
摘要翻译： 本发明提供了将非Treg转化为Treg的方法和组合物。 转化的Treg被称为可诱导Treg（iTreg）。 iTregs可用于预防，抑制，阻断或抑制免疫应答。 例如，iTreg可用于防止人或其他动物宿主中移植组织的排斥，或防止移植物抗宿主病。 iTreg也可用于治疗自身免疫性疾病。
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