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    Treatment of CNS Disorders With trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine
    2.
    发明申请
    Treatment of CNS Disorders With trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine 有权
    用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理中枢神经系统疾病

    公开(公告)号：US20080280993A1

    公开(公告)日：2008-11-13

    申请号：US12173626

    申请日：2008-07-15

    申请人： Thomas P. Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    发明人： Thomas P. Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    IPC分类号： A61K31/136 ,  A61P25/28

    CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2602/28

    摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

    摘要翻译： 用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。 还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。 该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。

    Treatment of CNS Disorders With trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine
    4.
    发明申请
    Treatment of CNS Disorders With trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine 有权
    用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理中枢神经系统疾病

    公开(公告)号：US20090292026A1

    公开(公告)日：2009-11-26

    申请号：US12538583

    申请日：2009-08-10

    申请人： Thomas P. Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    发明人： Thomas P. Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    IPC分类号： A61K31/135 ,  A61P25/00

    CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2602/28

    摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

    摘要翻译： 用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。 还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。 该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。

    Tramadol analogs and uses thereof
    5.
    发明授权
    Tramadol analogs and uses thereof 有权
    曲马多类似物及其用途

    公开(公告)号：US06780891B2

    公开(公告)日：2004-08-24

    申请号：US10308878

    申请日：2002-12-02

    申请人： Chris Hugh Senanayake ,  Thomas P. Jerussi ,  Paul T. Grover ,  Qun Kevin Fang ,  Mark Currie

    发明人： Chris Hugh Senanayake ,  Thomas P. Jerussi ,  Paul T. Grover ,  Qun Kevin Fang ,  Mark Currie

    IPC分类号： C07C21101

    CPC分类号： C07C217/74 ,  C07C217/52 ,  C07C255/59 ,  C07C2601/02 ,  C07C2601/14

    摘要： Compounds of formula I are effective in treating disorders modulated by opiate receptor activity and/or monoamine activity. In formula I, R1 is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl; R2 is selected from hydrogen, hydroxy, cyano, haloalkyl, glycosyl, SO2R5, and OR5; R3 and R4 are independently selected from hydrogen and lower alkyl, or R3 and R4 taken together with nitrogen form a five- or six-membered heterocyclic or substituted heterocyclic ring; and R5 is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl.

    摘要翻译： 式I化合物在治疗由阿片剂受体活性和/或单胺活性调节的病症中是有效的。在式I中，R 1选自烷基，芳基，烷基芳基，取代的烷基，取代的芳基和取代的烷基芳基; R 2选自氢，羟基，氰基，卤代烷基，糖基，SO 2 R 5和OR 5; R 3和R 4独立地选自氢和低级烷基，或R 3和R 4与氮一起形成五元或六元杂环或取代的杂环; R 5选自烷基，芳基，烷基芳基，取代的烷基，取代的芳基和取代的烷基芳基。

    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
    6.
    发明授权
    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine 有权
    用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症

    公开(公告)号：US07790772B2

    公开(公告)日：2010-09-07

    申请号：US12538583

    申请日：2009-08-10

    申请人： Thomas Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    发明人： Thomas Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    IPC分类号： A61K31/135 ,  C07C211/42

    CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2602/28

    摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

    摘要翻译： 用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。 还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。 该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。

    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
    8.
    发明授权
    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine 有权
    用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症

    公开(公告)号：US07423179B2

    公开(公告)日：2008-09-09

    申请号：US11416586

    申请日：2006-05-03

    申请人： Thomas Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    发明人： Thomas Jerussi ,  Qun Kevin Fang ,  Mark G. Currie

    IPC分类号： C07C211/42

    CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2602/28

    摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

    摘要翻译： 用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。 还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。 该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。