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公开(公告)号：US5153192A
公开(公告)日：1992-10-06
申请号：US618765
申请日：1990-11-27
申请人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
发明人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
IPC分类号： A61K31/38 , A61K20060101 , A61K31/381 , A61K31/435 , A61K31/54 , A61P9/12 , A61P27/02 , A61P43/00 , C07D20060101 , C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/00 , C07D513/04
CPC分类号： C07D409/04 , C07D333/34 , C07D333/38 , C07D495/04 , C07D513/04
摘要： Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
摘要翻译： 公开了噻吩磺酰胺和含有用于控制眼内压的化合物的药物组合物。 还公开了通过施用组合物来控制眼内压的方法。
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公开(公告)号：US06960579B1
公开(公告)日：2005-11-01
申请号：US09674403
申请日：1999-05-10
IPC分类号： C07D209/08 , C07D295/088 , C07D295/13 , C07D513/04 , A61K31/443 , A61K31/4965 , C07D241/02 , C07D279/02 , C07D401/12
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
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公开(公告)号：US5538966A
公开(公告)日：1996-07-23
申请号：US374470
申请日：1995-01-20
申请人： Jesse A. May , Hwang-Hsing Chen , Brian DuPr e , Thomas R. Dean
发明人： Jesse A. May , Hwang-Hsing Chen , Brian DuPr e , Thomas R. Dean
IPC分类号： A61K45/06 , C07D333/34 , C07D513/04 , C07D417/02 , A61K31/54
CPC分类号： C07D333/34 , A61K45/06 , C07D513/04
摘要： Compounds of the following formula are disclosed:Compounds of Formula I are the topic of this invention: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from ##STR2## The compounds are useful as carbonic anhydrase inhibitors.
摘要翻译： 公开了下式的化合物：式I化合物是本发明的主题：其中G，J和它们连接的噻吩环的两个原子形成六元环，其选自
或 该化合物可用作碳酸酐酶抑制剂。 -
公开(公告)号：US5378703A
公开(公告)日：1995-01-03
申请号：US019011
申请日：1993-02-18
申请人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
发明人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
IPC分类号： C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/04 , A61K31/54
CPC分类号： C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
摘要翻译： 公开了含有可用于控制眼内压的化合物的磺酰胺和药物组合物。 还公开了通过施用组合物来控制眼内压的方法。
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公开(公告)号：US5240923A
公开(公告)日：1993-08-31
申请号：US775313
申请日：1991-10-09
申请人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
发明人： Thomas R. Dean , Hwang-Hsing Chen , Jesse A. May
IPC分类号： A61K31/38 , A61K20060101 , A61K31/381 , A61K31/435 , A61K31/54 , A61P9/12 , A61P27/02 , A61P43/00 , C07D20060101 , C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/00 , C07D513/04
CPC分类号： C07D409/04 , C07D333/34 , C07D333/38 , C07D495/04 , C07D513/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
摘要翻译： 公开了含有可用于控制眼内压的化合物的磺酰胺和药物组合物。 还公开了通过施用组合物来控制眼内压的方法。
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6.发明授权Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders 有权用于治疗眼睛和CNS疾病的5-羟色胺能5HT7受体化合物公开(公告)号：US07285553B2
公开(公告)日：2007-10-23
申请号：US11265030
申请日：2005-11-02
IPC分类号： C07D403/00 , C07D401/00 , C07D241/04 , A61K31/495
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
摘要翻译： 公开了可用于降低IOP，改善视神经头和视网膜的血流量，提供神经保护和治疗视网膜疾病的具有5HT 7受体亲和力（其中一些是新颖的）的化合物。 化合物还可用于治疗睡眠障碍，抑郁症和其他精神病学障碍，例如精神分裂症，焦虑症，强迫症，昼夜节律紊乱以及中枢和外周介导的高血压。 还公开了其使用的组合物和方法。
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公开(公告)号：US5585377A
公开(公告)日：1996-12-17
申请号：US362716
申请日：1994-12-23
申请人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
发明人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
IPC分类号： C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/04 , A61K31/54
CPC分类号： C07D513/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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公开(公告)号：US07060704B2
公开(公告)日：2006-06-13
申请号：US11100918
申请日：2005-04-07
IPC分类号： C07D241/02 , C07D279/02 , C07D401/12 , A61K31/443 , A61K31/4965
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
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公开(公告)号：US07012090B1
公开(公告)日：2006-03-14
申请号：US10220924
申请日：2000-11-14
申请人： Jesse A. May , Hwang-Hsing Chen
发明人： Jesse A. May , Hwang-Hsing Chen
IPC分类号： A61K31/404 , C07P491/052 , A61P27/06
CPC分类号： C07D491/04
摘要： Substituted pyranoindoles useful for lowering and controlling IOP and glaucoma are disclosed.
摘要翻译： 公开了用于降低和控制IOP和青光眼的取代的吡喃吲哚。
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公开(公告)号：US5681834A
公开(公告)日：1997-10-28
申请号：US566640
申请日：1995-12-04
IPC分类号： C07D513/14 , A61K31/54
CPC分类号： C07D513/14
摘要： Compounds of the following structure are disclosed: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached are the group ##STR2##
摘要翻译： 公开了以下结构的化合物：其中G，J和它们所连接的噻吩环的两个原子是
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