公开(公告)号：US20240238429A1

公开(公告)日：2024-07-18

申请号：US18241744

申请日：2023-09-01

申请人： Thornhill Therapeutics, Inc

发明人： Randall J. Mrsny ,  Tahir Mahmood ,  Charles Olson ,  Weijun Feng

IPC分类号： A61K47/64 ,  A61K38/20 ,  A61P1/00 ,  C07K1/18

CPC分类号： A61K47/642 ,  A61K38/20 ,  A61P1/00 ,  C07K1/18

摘要： The present disclosure provides non-naturally occurring fusion molecules comprising therapeutic cargo moieties, such as IL-22 with a carrier. The disclosure also provides methods and compositions for the production, purification, refolding, formulation, and administration of fusion molecules. Methods and for using the purified molecules to treat and prevent diseases or disorders are also provided herein.