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1.发明授权Substituted oxindole derivatives and their use as vasopressin receptor ligands 有权取代的羟吲哚衍生物及其作为血管加压素受体配体的用途公开(公告)号：US08815868B2
公开(公告)日：2014-08-26
申请号：US12521713
申请日：2007-12-28
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与其组合的药物及其用于预防和/或治疗疾病的用途。
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2.发明授权Substituted oxindole derivatives, medicaments containing said derivatives and use thereof 有权取代的羟吲哚衍生物，含有所述衍生物的药物及其用途公开(公告)号：US08044079B2
公开(公告)日：2011-10-25
申请号：US12095594
申请日：2006-12-01
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4525 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivative of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in Claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防 和/或加压素依赖性疾病的治疗。
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3.发明授权Substituted oxindole derivatives, medicaments containing said derivatives and use thereof 有权取代的羟吲哚衍生物，含有所述衍生物的药物及其用途公开(公告)号：US09006276B2
公开(公告)日：2015-04-14
申请号：US13243166
申请日：2011-09-23
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D401/12 , A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4525 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防 和/或加压素依赖性疾病的治疗。
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4.发明授权Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses 有权酰胺甲基取代的羟基吲哚衍生物及其用于治疗加压素依赖性疾病的用途公开(公告)号：US08703775B2
公开(公告)日：2014-04-22
申请号：US12746700
申请日：2008-12-05
申请人： Thorsten Oost , Astrid Netz , Herve Geneste , Wilfried Braje , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Thorsten Oost , Astrid Netz , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的酰胺甲基取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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5.发明申请公开(公告)号：US20130029966A1
公开(公告)日：2013-01-31
申请号：US13243166
申请日：2011-09-23
申请人： Thorsten Oost , Wilfried Lubisch , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： A61K31/496 , A61K31/454 , A61K31/5377 , A61K31/551 , C07D413/14 , C07D413/12 , A61K31/427 , C07D417/14 , A61K31/4439 , C07D401/14 , A61P3/10 , A61P13/02 , A61P7/02 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/00 , A61P1/16 , A61P1/04 , A61P1/08 , A61P25/28 , A61P25/24 , A61P25/30 , A61K31/422
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in Claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
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6.发明申请SUBSTITUTED OXINDOLE DERIVATIVES AND THEIR USE AS VASOPRESSIN RECEPTOR LIGANDS 有权取代的氧化衍生物及其作为血管收缩素受体配体使用公开(公告)号：US20120322809A1
公开(公告)日：2012-12-20
申请号：US13590261
申请日：2012-08-21
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
IPC分类号： C07D409/14 , A61K31/4545 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/00 , A61P1/04 , A61K31/496 , A61P9/12
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与包含它们的药物及其用于预防和/或治疗依赖于加压素的疾病的用途。
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7.发明授权Substituted oxindole derivatives and their use as vasopressin receptor ligands 有权取代的羟吲哚衍生物及其作为血管加压素受体配体的用途公开(公告)号：US08859557B2
公开(公告)日：2014-10-14
申请号：US13590261
申请日：2012-08-21
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Martin Braje , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Martin Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/14
CPC分类号： A61K31/506 , A61K31/4545 , C07D401/14
摘要： The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物与包含它们的药物及其用于预防和/或治疗依赖于加压素的疾病的用途。
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8.发明申请SUBSTITUTED OXINDOL DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF 有权取代的氧化物衍生物，含有该衍生物的药物及其用途公开(公告)号：US20100273766A1
公开(公告)日：2010-10-28
申请号：US12095594
申请日：2006-12-01
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： A61K31/422 , C07D413/14 , A61K31/496 , A61P3/10 , A61P13/00 , A61P7/00 , A61P9/10 , A61P13/12 , A61P1/08 , A61P1/16 , A61P25/22 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/30 , A61K31/454 , A61K31/5377 , A61K31/551 , C07D417/14 , A61K31/427 , C07D401/14 , A61K31/4439 , A61K31/4245
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防 和/或加压素依赖性疾病的治疗。
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9.发明授权Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases 有权氨基甲酸酯取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途公开(公告)号：US08703774B2
公开(公告)日：2014-04-22
申请号：US12746688
申请日：2008-12-05
申请人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Andrea Hager-Wernet
发明人： Astrid Netz , Thorsten Oost , Herve Geneste , Wilfried Braje , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
摘要翻译： 本发明涉及新的氨基甲酸酯取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素依赖性病症的用途。
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公开(公告)号：US07951807B2
公开(公告)日：2011-05-31
申请号：US11632462
申请日：2005-07-13
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
IPC分类号： A61K31/404 , A61K31/454 , C07D209/34 , C07D401/12
CPC分类号： C07D401/12 , C07D209/34
摘要： The present invention relates to novel oxindole derivatives of the general formula (I), wherein the substituents A, B, R1, R2 and R3 are as defined in Claim 1, and medicaments containing the same for the prophylaxis and/or treatment of vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基A，B，R 1，R 2和R 3如权利要求1所定义，以及含有其的用于预防和/或治疗加压素 - 依赖性或催产素依赖性疾病。
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