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    SUBSTITUTED OXINDOLE COMPOUNDS
    10.
    发明申请
    SUBSTITUTED OXINDOLE COMPOUNDS 有权
    取代的氧化物

    公开(公告)号：US20100286165A1

    公开(公告)日：2010-11-11

    申请号：US12529542

    申请日：2008-02-29

    申请人： Herve' Geneste ,  Thorsten Oost ,  Charles W Hutchins ,  Wolfgang Wernet ,  Liliane Unger ,  Wilfried Hornberger ,  Wilfried Lubisch ,  Astrid Netz

    发明人： Herve' Geneste ,  Thorsten Oost ,  Charles W Hutchins ,  Wolfgang Wernet ,  Liliane Unger ,  Wilfried Hornberger ,  Wilfried Lubisch ,  Astrid Netz

    IPC分类号： A61K31/444 ,  C07D401/14 ,  A61K31/496 ,  A61P9/12 ,  A61P11/00 ,  A61P9/10 ,  A61P9/00 ,  A61P1/04 ,  A61P1/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/30

    CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D471/08

    摘要： The present invention relates to compounds of the general formula (I) in which A, B, R1, R2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula in which D is C1-C3-alkylene, where D may have a substituent R5; R3 is hydrogen, C1-C8-alkyl or together with R4 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, and R4 is hydrogen, C1-C8-alkyl or together with R3 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, where R5 together with R5a, where present, are a bond or C1-C3-alkylene; and where one of the following conditions is satisfied: R3 together with R4 is C1-C3-alkylene which may have a radical R5a; or R3 together with R5 is C1-C3-alkylene; or R4 together with R5 is C1-C3-alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.

    摘要翻译： 本发明涉及通式（I）的化合物，其中A，B，R1，R2和Het具有权利要求1中给出的含义; Y是下式的二价基团，其中D是C 1 -C 3 - 亚烷基，其中D可以具有取代基R 5; R 3是氢，C 1 -C 8烷基或与R 4一起是可以具有基团R 5a的C 1 -C 3亚烷基，或与R 5一起为C 1 -C 3 - 亚烷基，并且R 4是氢，C 1 -C 8 - 烷基或与 R 3是可以具有基团R 5a的C 1 -C 3亚烷基，或与R 5一起为C 1 -C 3 - 亚烷基，其中R 5与存在的R a a为键或C 1 -C 3 - 亚烷基; 并且其中满足以下条件之一：R 3与R 4一起可以具有基团R 5a的C 1 -C 3 - 亚烷基; 或R 3与R 5一起为C 1 -C 3 - 亚烷基; 或R 4与R 5一起为C 1 -C 3 - 亚烷基，其中基团B为苯基或萘基时，基团A不同于苯基; 以及包含这些化合物的药物及其用于预防和/或治疗加压素依赖性和/或催产素依赖性疾病的用途。