公开(公告)号：US10525146B2

公开(公告)日：2020-01-07

申请号：US16385519

申请日：2019-04-16

申请人： Tijana Rajh ,  Elena A. Rozhkova ,  Harry C. Fry ,  Nada Dimitrijevic ,  Tamara Koritarov

发明人： Tijana Rajh ,  Elena A. Rozhkova ,  Harry C. Fry ,  Nada Dimitrijevic ,  Tamara Koritarov ,  Bartosz Gryzbowski

IPC分类号： A61K47/68 ,  A61K47/69 ,  C12Q1/66 ,  A61K49/12

摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.