公开(公告)号：US09107895B2

公开(公告)日：2015-08-18

申请号：US12843664

申请日：2010-07-26

申请人： Bulent Aydogan ,  Tijana Rajh

发明人： Bulent Aydogan ,  Tijana Rajh

IPC分类号： C07H23/00 ,  A61K33/24 ,  A61K31/7135 ,  A61K49/00 ,  A61K9/14 ,  A61K49/04 ,  A61P43/00 ,  A61K31/7004 ,  B82Y5/00

CPC分类号： A61K33/24 ,  A61K31/7004 ,  A61K49/0485 ,  B82Y5/00 ,  C07H23/00

摘要： Disclosed are compositions comprising nanoparticles and uses thereof. Such nanoparticles include gold nanoparticles conjugated to glucose or a glucose derivative, which are useful as contrast agents in imaging methods such as computed tomography (CT). Nanoparticles disclosed herein are useful in imaging various cells, tissues, and organs, and are particularly useful in imaging tumors and tumor cells in vitro and in vivo.

摘要翻译： 公开了包含纳米颗粒的组合物及其用途。 这样的纳米颗粒包括与葡萄糖或葡萄糖衍生物缀合的金纳米颗粒，其可用作成像方法如计算机断层摄影（CT）中的造影剂。 本文公开的纳米颗粒可用于成像各种细胞，组织和器官，并且特别可用于体外和体内成像肿瘤和肿瘤细胞。

公开(公告)号：US06410935B1

公开(公告)日：2002-06-25

申请号：US09858791

申请日：2001-05-16

申请人： Tijana Rajh ,  Natalia Meshkov ,  Jovan M. Nedelijkovic ,  Laura R. Skubal ,  David M. Tiede ,  Marion Thurnauer

发明人： Tijana Rajh ,  Natalia Meshkov ,  Jovan M. Nedelijkovic ,  Laura R. Skubal ,  David M. Tiede ,  Marion Thurnauer

IPC分类号： H01L2912

CPC分类号： B82Y30/00 ,  B82B1/00 ,  H01L21/76838 ,  Y10S977/712 ,  Y10S977/773 ,  Y10S977/778 ,  Y10S977/887 ,  Y10S977/901

摘要： An article of manufacture and method of forming nanoparticle sized material components. A semiconductor oxide substrate includes nanoparticles of semiconductor oxide. A modifier is deposited onto the nanoparticles, and a source of metal ions are deposited in association with the semiconductor and the modifier, the modifier enabling electronic hole scavenging and chelation of the metal ions. The metal ions and modifier are illuminated to cause reduction of the metal ions to metal onto the semiconductor nanoparticles.

摘要翻译： 纳米颗粒尺寸的材料成分的制造方法和方法。 半导体氧化物衬底包括半导体氧化物的纳米颗粒。 改性剂沉积到纳米颗粒上，并且与半导体和改性剂相关联地沉积金属离子源，该改性剂使电子空穴清除和螯合金属离子。 照射金属离子和改性剂以使金属离子金属还原成半导体纳米颗粒。

公开(公告)号：US20070105013A1

公开(公告)日：2007-05-10

申请号：US11605840

申请日：2006-11-28

申请人： Tijana Rajh ,  YuPo Lin ,  Nada Dimitrijevic ,  Seth Snyder ,  Norman Sather

发明人： Tijana Rajh ,  YuPo Lin ,  Nada Dimitrijevic ,  Seth Snyder ,  Norman Sather

IPC分类号： H01M4/00

CPC分类号： C01B3/042 ,  C01B3/503 ,  C01B13/0207 ,  C01B13/0255 ,  C01B2203/041 ,  C01B2203/0465 ,  C01B2203/047 ,  C01B2203/0475 ,  C01B2210/0053 ,  H01M8/0606 ,  Y02E60/364 ,  Y02P20/134 ,  Y02P20/135 ,  Y02P30/30

摘要： The invention provides a system for separating oppositely-charged charge carriers, the substrate comprising a semiconductor; a ligand in electrical communication with said semiconductor; an ion-exchange resin attached to the semiconductor; an ion-exchange membrane; and an electrical conduit attaching said resin to said membrane. Also provided is a method for producing hydrogen gas, comprising: inducing charge separation in semiconductor particles so as to produce electrons and holes; oxidizing water with the holes to produce oxygen ions and protons, wherein the protons are sequestered from the oxygen ions as the protons are produced; and directing the sequestered protons to a cathode. The invention also provides a method to produce electricity comprising, inducing charge separation in semiconductor particles so as to produce electrons and holes, and completing the circuit with an electron hole transporter.

摘要翻译： 本发明提供了一种用于分离带正电荷的电荷载体的系统，所述衬底包括半导体; 与所述半导体电连通的配体; 附着在半导体上的离子交换树脂; 离子交换膜; 以及将所述树脂附着到所述膜上的电导管。 还提供了一种生产氢气的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴; 用空穴氧化水以产生氧离子和质子，其中当产生质子时，质子与氧离子隔离; 并将螯合的质子引导到阴极。 本发明还提供一种产生电的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴，并用电子空穴传输器完成电路。

公开(公告)号：US06677606B1

公开(公告)日：2004-01-13

申请号：US09606429

申请日：2000-06-28

申请人： Tijana Rajh ,  Tatjana Paunesku ,  Gayle E. Woloschak ,  Marion C. Thurnauer

发明人： Tijana Rajh ,  Tatjana Paunesku ,  Gayle E. Woloschak ,  Marion C. Thurnauer

IPC分类号： H01L3524

CPC分类号： G01N27/3278

摘要： A method is provided for selective binding and detecting target molecules, and a method for detecting biological molecules, the method comprising supplying a semi-conductor capable of charge pair separation, and juxtaposing affinity moieties to the semi-conductor so as to effect changes in the charge pair separation characteristics when the affinity molecules are bound to the target molecules.

摘要翻译： 提供了用于选择性结合和检测靶分子的方法，以及用于检测生物分子的方法，所述方法包括提供能够进行电荷对分离的半导体，并且将并联亲和部分并入到半导体中，以便实现 当亲和分子与目标分子结合时，电荷对分离特性。

公开(公告)号：US06271130B1

公开(公告)日：2001-08-07

申请号：US09200159

申请日：1998-11-25

申请人： Tijana Rajh ,  Natalia Meshkov ,  Jovan M. Nedelijkovic ,  Laura R. Skubal ,  David M. Tiede ,  Marion Thurnauer

发明人： Tijana Rajh ,  Natalia Meshkov ,  Jovan M. Nedelijkovic ,  Laura R. Skubal ,  David M. Tiede ,  Marion Thurnauer

IPC分类号： H01L2144

CPC分类号： B82Y30/00 ,  B82B1/00 ,  H01L21/76838 ,  Y10S977/712 ,  Y10S977/773 ,  Y10S977/778 ,  Y10S977/887 ,  Y10S977/901

摘要： An article of manufacture and method of forming nanoparticle sized material components. A semiconductor oxide substrate includes nanoparticles of semiconductor oxide. A modifier is deposited onto the nanoparticles, and a source of metal ions are deposited in association with the semiconductor and the modifier, the modifier enabling electronic hole scavenging and chelation of the metal ions. The metal ions and modifier are illuminated to cause reduction of the metal ions to metal onto the semiconductor nanoparticles.

摘要翻译： 纳米颗粒尺寸的材料成分的制造方法和方法。 半导体氧化物衬底包括半导体氧化物的纳米颗粒。 改性剂沉积到纳米颗粒上，并且与半导体和改性剂相关联地沉积金属离子源，该改性剂使电子空穴清除和螯合金属离子。 照射金属离子和改性剂以使金属离子金属还原成半导体纳米粒子。

公开(公告)号：US07981261B2

公开(公告)日：2011-07-19

申请号：US11605840

申请日：2006-11-28

申请人： Tijana Rajh ,  YuPo Lin ,  Nada Dimitrijevic ,  Seth W. Snyder ,  Norman F. Sather

发明人： Tijana Rajh ,  YuPo Lin ,  Nada Dimitrijevic ,  Seth W. Snyder ,  Norman F. Sather

IPC分类号： C25B9/00

CPC分类号： C01B3/042 ,  C01B3/503 ,  C01B13/0207 ,  C01B13/0255 ,  C01B2203/041 ,  C01B2203/0465 ,  C01B2203/047 ,  C01B2203/0475 ,  C01B2210/0053 ,  H01M8/0606 ,  Y02E60/364 ,  Y02P20/134 ,  Y02P20/135 ,  Y02P30/30

摘要： The invention provides a system for separating oppositely-charged charge carriers, the substrate comprising a semiconductor; a ligand in electrical communication with said semiconductor; an ion-exchange resin attached to the semiconductor; an ion-exchange membrane; and an electrical conduit attaching said resin to said membrane. Also provided is a method for producing hydrogen gas, comprising: inducing charge separation in semiconductor particles so as to produce electrons and holes; oxidizing water with the holes to produce oxygen ions and protons, wherein the protons are sequestered from the oxygen ions as the protons are produced; and directing the sequestered protons to a cathode. The invention also provides a method to produce electricity comprising, inducing charge separation in semiconductor particles so as to produce electrons and holes, and completing the circuit with an electron hole transporter.

摘要翻译： 本发明提供了一种用于分离带正电荷的电荷载体的系统，所述衬底包括半导体; 与所述半导体电连通的配体; 附着在半导体上的离子交换树脂; 离子交换膜; 以及将所述树脂附着到所述膜上的电导管。 还提供了一种生产氢气的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴; 用空穴氧化水以产生氧离子和质子，其中当产生质子时，质子与氧离子隔离; 并将螯合的质子引导到阴极。 本发明还提供一种产生电的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴，并用电子空穴传输器完成电路。

公开(公告)号：US20100078066A1

公开(公告)日：2010-04-01

申请号：US12489001

申请日：2009-06-22

申请人： Seth B. Darling ,  Sanja Tepavcevic ,  Tijana Rajh ,  Nada Dimitrijevic ,  Steven J. Sibener

发明人： Seth B. Darling ,  Sanja Tepavcevic ,  Tijana Rajh ,  Nada Dimitrijevic ,  Steven J. Sibener

IPC分类号： H01L51/46 ,  H01L51/48

CPC分类号： H01L51/4226 ,  H01L51/0036 ,  Y02E10/549 ,  Y02P70/521

摘要： A hybrid photovoltaic cell comprising a composite substrate of a nanotube or nanorod array of metal oxide infiltrated with a monomer precursor and subsequently polymerized in situ via UV irradiation. In an embodiment, the photovoltaic cell comprises an electron accepting TiO2 nanotube array infiltrated with a photo-sensitive electron donating conjugated polymer. The conjugated polymer may be formed in situ through UV irradiation polymerizing a monomer precursor such as 2,5-diiodothiophene (DIT).

摘要翻译： 一种混合光伏电池，其包含纳米管或纳米棒阵列的金属氧化物的复合衬底，所述金属氧化物浸入单体前体中，随后通过UV照射原位聚合。 在一个实施方案中，光伏电池包括渗透有感光电子给予共轭聚合物的电子接受TiO 2纳米管阵列。 共轭聚合物可以通过UV照射原位形成聚合单体前体如2,5-二碘噻吩（DIT）。

公开(公告)号：US10525146B2

公开(公告)日：2020-01-07

申请号：US16385519

申请日：2019-04-16

申请人： Tijana Rajh ,  Elena A. Rozhkova ,  Harry C. Fry ,  Nada Dimitrijevic ,  Tamara Koritarov

发明人： Tijana Rajh ,  Elena A. Rozhkova ,  Harry C. Fry ,  Nada Dimitrijevic ,  Tamara Koritarov ,  Bartosz Gryzbowski

IPC分类号： A61K47/68 ,  A61K47/69 ,  C12Q1/66 ,  A61K49/12

摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.

公开(公告)号：US20190240347A1

公开(公告)日：2019-08-08

申请号：US16385519

申请日：2019-04-16

申请人： Tijana RAJH ,  Elena A. ROZHKOVA ,  Harry C. FRY ,  Nada DIMITRIJEVIC ,  Tamara KORITAROV ,  Bartosz Gryzbowski

发明人： Tijana RAJH ,  Elena A. ROZHKOVA ,  Harry C. FRY ,  Nada DIMITRIJEVIC ,  Tamara KORITAROV ,  Bartosz Gryzbowski

IPC分类号： A61K47/68 ,  C12Q1/66 ,  A61K49/12 ,  A61K47/69

CPC分类号： A61K47/6863 ,  A61K47/6923 ,  A61K49/12 ,  C12Q1/66

摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.

公开(公告)号：US08269100B2

公开(公告)日：2012-09-18

申请号：US12489001

申请日：2009-06-22

申请人： Seth B. Darling ,  Sanja Tepavcevic ,  Tijana Rajh ,  Nada Dimitrijevic ,  Steven J. Sibener

发明人： Seth B. Darling ,  Sanja Tepavcevic ,  Tijana Rajh ,  Nada Dimitrijevic ,  Steven J. Sibener

IPC分类号： H01L31/00 ,  H01L21/00

CPC分类号： H01L51/4226 ,  H01L51/0036 ,  Y02E10/549 ,  Y02P70/521

摘要： A hybrid photovoltaic cell comprising a composite substrate of a nanotube or nanorod array of metal oxide infiltrated with a monomer precursor and subsequently polymerized in situ via UV irradiation. In an embodiment, the photovoltaic cell comprises an electron accepting TiO2 nanotube array infiltrated with a photo-sensitive electron donating conjugated polymer. The conjugated polymer may be formed in situ through UV irradiation polymerizing a monomer precursor such as 2,5-diiodothiophene (DIT).

摘要翻译： 一种混合光伏电池，其包含纳米管或纳米棒阵列的金属氧化物的复合衬底，所述金属氧化物浸入单体前体中，随后通过UV照射原位聚合。 在一个实施方案中，光伏电池包括渗透有感光电子给予共轭聚合物的电子接受TiO 2纳米管阵列。 共轭聚合物可以通过UV照射原位形成聚合单体前体如2,5-二碘噻吩（DIT）。