公开(公告)号：US20160250232A1

公开(公告)日：2016-09-01

申请号：US15028863

申请日：2013-10-29

申请人： TILLOTTS PHARMA AG

发明人： Felipe Jose Oliveira VARUM ,  Roberto Carlos BRAVO GONZALEZ ,  Thomas BUSER ,  Abdul Waseh BASIT ,  Ana Cristina FREIRE

IPC分类号： A61K31/606 ,  A61K9/28 ,  A61J3/00 ,  A61K9/00

摘要： In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.

摘要翻译： 在包含含有药物的芯和用于提供肠释放的延迟释放包衣的延迟释放制剂中，通过在芯和延迟释放包衣之间包括隔离层来加速药物在结肠中的释放。 延迟释放涂层包括内层和外层。 外层包含pH约为5或更高pH值的pH依赖性聚合物。 内层包含可溶于肠液或胃肠液的可溶性聚合材料，所述可溶性聚合物材料选自至少部分中和的多元羧酸聚合物和非离子聚合物， 其中所述可溶性聚合物材料是非离子聚合物，所述内层包含至少一种选自缓冲剂和碱的添加剂。

公开(公告)号：US20170266117A1

公开(公告)日：2017-09-21

申请号：US15612065

申请日：2017-06-02

申请人： Tillotts Pharma AG

发明人： Felipe Josè OLIVEIRA VARUM ,  Roberto Carlos BRAVO GONZÁLEZ ,  Thomas BUSER ,  Abdul Waseh BASIT ,  Ana Cristina FREIRE

IPC分类号： A61K9/28 ,  A61K31/196 ,  A61K31/606 ,  A61K31/616 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K9/00 ,  A61K9/20

摘要： In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.

公开(公告)号：US20170035698A1

公开(公告)日：2017-02-09

申请号：US15267156

申请日：2016-09-16

申请人： Tillotts Pharma AG

发明人： Felipe Josè OLIVEIRA VARUM ,  Roberto Carlos BRAVO GONZÁLEZ ,  Thomas BUSER ,  Abdul Waseh BASIT ,  Ana Cristina FREIRE

IPC分类号： A61K9/28 ,  A61K9/20

CPC分类号： A61K9/2886 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/286 ,  A61K9/2866 ,  A61K9/288 ,  A61K9/2893 ,  A61K31/196 ,  A61K31/606 ,  A61K31/616 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

摘要： In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.

摘要翻译： 在包含含有药物的芯和用于提供肠释放的延迟释放包衣的延迟释放制剂中，通过在芯和延迟释放包衣之间包括隔离层来加速药物在结肠中的释放。 延迟释放涂层包括内层和外层。 外层包含pH约为5或更高pH值的pH依赖性聚合物。 内层包含可溶于肠液或胃肠液的可溶性聚合材料，所述可溶性聚合物材料选自至少部分中和的多元羧酸聚合物和非离子聚合物， 其中所述可溶性聚合物材料是非离子聚合物，所述内层包含至少一种选自缓冲剂和碱的添加剂。