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13 条记录 (耗时 0.03 秒)

    Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
    1.
    发明授权
    Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan 有权
    结晶D-异谷氨酰-D-色氨酸和D-异谷氨酰-D-色氨酸的单铵盐

    公开(公告)号：US08119606B2

    公开(公告)日：2012-02-21

    申请号：US12515217

    申请日：2007-11-26

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Tuong ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Tuong ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： A61K38/05

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.

    摘要翻译： 提供了制备纯结晶D-异谷氨酰-D-色氨酸的方法，其包括使基本上纯的N-叔丁氧基羰基-D-异谷氨酰-D-色氨酸或其二酯脱保护的步骤，得到基本上纯的D-异谷氨酰基-D-色氨酸 。 还提供了从基本上纯的N-叔丁氧基羰基-D-异谷氨酰-D-色氨酸制备D-异谷氨酰-D-色氨酸的纯单一铵盐的方法。 D-异谷氨酰基-D-色氨酸，铵盐（1:1））是稳定的药物固体。

    Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture
    2.
    发明申请
    Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture 有权
    胸腺抑素的药学上可接受的盐及其制造方法

    公开(公告)号：US20100056803A1

    公开(公告)日：2010-03-04

    申请号：US12520337

    申请日：2007-12-13

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Tuong ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Tuong ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： C07D209/12

    CPC分类号： C07D209/20 ,  A61K38/05 ,  C07K5/0215

    摘要： The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D- tryptophan organic ammonium salts (1:1).

    摘要翻译： 本发明涉及D-异谷氨酰-D-色氨酸的药学上可接受的结晶和无定形盐以及其制备方法，包含它们的药物组合物及其在制备药物组合物中用于治疗各种病症和/或 疾病 特别地，本发明涉及D-异谷氨酰-D-色氨酸钾盐（1：1），D-异谷氨酰基-D-色氨酸锂盐（1:1），D-异谷氨酰-D-色氨酸钙盐（2： 1），D-异谷氨酰-D-色氨酸镁盐（2:1）和D-异谷氨酰基-D-色氨酸有机铵盐（1:1）。

    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
    5.
    发明授权
    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture 有权
    胸腺抑素的药学上可接受的盐及其制造方法

    公开(公告)号：US08138221B2

    公开(公告)日：2012-03-20

    申请号：US12520337

    申请日：2007-12-13

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： A61K31/404 ,  C07D209/12

    CPC分类号： C07D209/20 ,  A61K38/05 ,  C07K5/0215

    摘要： The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D-tryptophan organic ammonium salts (1:1).

    摘要翻译： 本发明涉及D-异谷氨酰-D-色氨酸的药学上可接受的结晶和无定形盐以及其制备方法，包含它们的药物组合物及其在制备药物组合物中用于治疗各种病症和/或 疾病 特别地，本发明涉及D-异谷氨酰-D-色氨酸钾盐（1：1），D-异谷氨酰基-D-色氨酸锂盐（1:1），D-异谷氨酰-D-色氨酸钙盐（2： 1），D-异谷氨酰-D-色氨酸镁盐（2:1）和D-异谷氨酰-D-色氨酸有机铵盐（1:1）。

    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
    6.
    发明授权
    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture 有权
    胸腺抑素的药学上可接受的盐及其制造方法

    公开(公告)号：US08735602B2

    公开(公告)日：2014-05-27

    申请号：US13424343

    申请日：2012-03-19

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： C07D209/12

    CPC分类号： C07D209/20 ,  A61K38/05 ,  C07K5/0215

    摘要： The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D-tryptophan organic ammonium salts (1:1).

    摘要翻译： 本发明涉及D-异谷氨酰-D-色氨酸的药学上可接受的结晶和无定形盐以及其制备方法，包含它们的药物组合物及其在制备药物组合物中用于治疗各种病症和/或 疾病 特别地，本发明涉及D-异谷氨酰-D-色氨酸钾盐（1：1），D-异谷氨酰基-D-色氨酸锂盐（1:1），D-异谷氨酰-D-色氨酸钙盐（2： 1），D-异谷氨酰-D-色氨酸镁盐（2:1）和D-异谷氨酰-D-色氨酸有机铵盐（1:1）。

    Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
    10.
    发明授权
    Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan 失效
    结晶D-异谷氨酰-D-色氨酸和D-异谷氨酰-D-色氨酸的单铵盐

    公开(公告)号：US08507449B2

    公开(公告)日：2013-08-13

    申请号：US13400303

    申请日：2012-02-20

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： C07K5/072 ,  A61K38/05

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.

    摘要翻译： 提供了制备纯结晶D-异谷氨酰-D-色氨酸的方法，其包括使基本上纯的N-叔丁氧基羰基-D-异谷氨酰-D-色氨酸或其二酯脱保护的步骤，得到基本上纯的D-异谷氨酰基-D-色氨酸 。 还提供了从基本上纯的N-叔丁氧基羰基-D-异谷氨酰-D-色氨酸制备D-异谷氨酰-D-色氨酸的纯单一铵盐的方法。 D-异谷氨酰基-D-色氨酸，铵盐（1:1））是稳定的药物固体。