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39 条记录 (耗时 0.081 秒)

    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
    1.
    发明授权
    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture 有权
    胸腺抑素的药学上可接受的盐及其制造方法

    公开(公告)号：US08735602B2

    公开(公告)日：2014-05-27

    申请号：US13424343

    申请日：2012-03-19

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： C07D209/12

    CPC分类号： C07D209/20 ,  A61K38/05 ,  C07K5/0215

    摘要： The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D-tryptophan organic ammonium salts (1:1).

    摘要翻译： 本发明涉及D-异谷氨酰-D-色氨酸的药学上可接受的结晶和无定形盐以及其制备方法，包含它们的药物组合物及其在制备药物组合物中用于治疗各种病症和/或 疾病 特别地，本发明涉及D-异谷氨酰-D-色氨酸钾盐（1：1），D-异谷氨酰基-D-色氨酸锂盐（1:1），D-异谷氨酰-D-色氨酸钙盐（2： 1），D-异谷氨酰-D-色氨酸镁盐（2:1）和D-异谷氨酰-D-色氨酸有机铵盐（1:1）。

    Fluorinated Derivatives of Deferiprone
    5.
    发明申请
    Fluorinated Derivatives of Deferiprone 有权
    去铁酮的氟化衍生物

    公开(公告)号：US20120095061A1

    公开(公告)日：2012-04-19

    申请号：US13245262

    申请日：2011-09-26

    申请人： Tim Fat Tam ,  Regis Leung-Toung ,  Yingsheng WANG ,  Yanqing Zhao

    发明人： Tim Fat Tam ,  Regis Leung-Toung ,  Yingsheng WANG ,  Yanqing Zhao

    IPC分类号： A61K31/4412 ,  A61P25/16 ,  A61P25/28

    CPC分类号： C07D309/40 ,  C07D213/69

    摘要： The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the manufacture thereof and their use in the treatment of neurodegenerative diseases caused by the presence of free iron or iron accumulation in neural tissues and in diseases wherein excess iron must be removed or redistributed.

    摘要翻译： 本发明涉及去铁酮的新型衍生物。 特别地，本发明涉及去铁酮的氟化衍生物或其药学上可接受的盐，包含其的药物组合物，其制备方法及其用于治疗由神经组织中游离铁或铁积聚引起的神经变性疾病的治疗 以及必须除去或重新分配过量铁的疾病。

    Fluorinated derivatives of deferiprone
    6.
    发明申请
    Fluorinated derivatives of deferiprone 有权
    去铁酮的氟化衍生物

    公开(公告)号：US20080242706A1

    公开(公告)日：2008-10-02

    申请号：US12078079

    申请日：2008-03-27

    申请人： Tim Fat Tam ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao

    发明人： Tim Fat Tam ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao

    IPC分类号： A61K31/44 ,  C07D213/69 ,  C07D309/32 ,  A61K31/35 ,  A61P25/16 ,  A61P25/28

    CPC分类号： C07D309/40 ,  C07D213/69

    摘要： The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the manufacture thereof and their use in the treatment of neurodegenerative diseases caused by the presence of free iron or iron accumulation in neural tissues and in diseases wherein excess iron must be removed or redistributed.

    摘要翻译： 本发明涉及去铁酮的新型衍生物。 特别地，本发明涉及去铁酮的氟化衍生物或其药学上可接受的盐，包含其的药物组合物，其制备方法及其用于治疗由神经组织中游离铁或铁积聚引起的神经变性疾病的治疗 以及必须除去或重新分配过量铁的疾病。

    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
    10.
    发明授权
    Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture 有权
    胸腺抑素的药学上可接受的盐及其制造方法

    公开(公告)号：US08138221B2

    公开(公告)日：2012-03-20

    申请号：US12520337

    申请日：2007-12-13

    申请人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    发明人： Tim Fat Tam ,  Blaise N'Zemba ,  Regis Leung-Toung ,  Yingsheng Wang ,  Yanqing Zhao ,  Lily Yu

    IPC分类号： A61K31/404 ,  C07D209/12

    CPC分类号： C07D209/20 ,  A61K38/05 ,  C07K5/0215

    摘要： The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D-tryptophan organic ammonium salts (1:1).

    摘要翻译： 本发明涉及D-异谷氨酰-D-色氨酸的药学上可接受的结晶和无定形盐以及其制备方法，包含它们的药物组合物及其在制备药物组合物中用于治疗各种病症和/或 疾病 特别地，本发明涉及D-异谷氨酰-D-色氨酸钾盐（1：1），D-异谷氨酰基-D-色氨酸锂盐（1:1），D-异谷氨酰-D-色氨酸钙盐（2： 1），D-异谷氨酰-D-色氨酸镁盐（2:1）和D-异谷氨酰-D-色氨酸有机铵盐（1:1）。