公开(公告)号：US10209241B2

公开(公告)日：2019-02-19

申请号：US14238624

申请日：2012-08-10

申请人： Tim Maguire ,  Martin L. Yarmush ,  Rene S. Schloss ,  Bhaskar Mitra ,  Rohit Jindal ,  Mehdi Ghodbane

发明人： Tim Maguire ,  Martin L. Yarmush ,  Rene S. Schloss ,  Bhaskar Mitra ,  Rohit Jindal ,  Mehdi Ghodbane

IPC分类号： C12M3/00 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  B01L3/00 ,  C12M3/06

摘要： This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.

公开(公告)号：US20140336078A1

公开(公告)日：2014-11-13

申请号：US14238624

申请日：2012-08-10

申请人： Tim Maguire ,  Martin L. Yarmush ,  Rene S. Schloss ,  Bhaskar Mitra ,  Rohit Jindal ,  Mehdi Ghodbane

发明人： Tim Maguire ,  Martin L. Yarmush ,  Rene S. Schloss ,  Bhaskar Mitra ,  Rohit Jindal ,  Mehdi Ghodbane

IPC分类号： G01N33/50

CPC分类号： G01N33/5023 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/086 ,  C12M23/16 ,  G01N33/5047 ,  G01N33/5064 ,  G01N33/5082 ,  G01N33/54366 ,  G01N33/6863 ,  G01N2333/7051 ,  G01N2333/70596 ,  G01N2333/7151 ,  G01N2333/7155 ,  G01N2500/10

摘要： This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.

摘要翻译： 本发明公开了用于高通量皮肤敏化检测的装置和方法。 所述装置包括微加工室，其包括具有一个或多个输入通道和出口的区域，以及适于安装皮肤组织并与该区域流体连通的面。 该装置可用于确定动物受试者的致敏预后的方法，并鉴定不引起致敏的化合物，因此适用于制备美容组合物。